One-pot synthesis of β-N-glycosyl imidazole analogues via a palladium-catalysed decarboxylative allylation.

Chem Commun (Camb)

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.

Published: April 2014

AI Article Synopsis

  • A new method for creating N-glycosyl imidazole compounds is introduced, which is efficient and straightforward.
  • It involves a palladium-catalyzed reaction that combines three key steps: carbamation, decarboxylation, and allylation.
  • The process results in high yields and selectivity for all starting materials used in the reaction.

Article Abstract

A concise and highly efficient strategy for the synthesis of N-glycosyl imidazole analogues is reported. This reaction is based on a palladium catalysed decarboxylative allylation and three steps, namely, carbamation, decarboxylation and allylation are involved. All the substrates can afford the desired products with excellent yields and selectivities.

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Source
http://dx.doi.org/10.1039/c3cc48041kDOI Listing

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