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The pattern of proline, glutamic acid, and leucine-rich protein 1 expression in Chinese women with primary breast cancer. | LitMetric

AI Article Synopsis

  • - The study examines PELP1 expression as a potential breast cancer biomarker among Chinese women, aiming to explore racial and ethnic differences in biomarker expression in breast cancer.
  • - Researchers analyzed PELP1 levels in tissue samples from 130 Chinese breast cancer patients and compared them to 26 benign cases, finding significantly higher PELP1 levels in cancerous tissues.
  • - Results indicate that higher PELP1 expression is linked to poor outcomes, especially in ER/HER-2-positive groups and in the luminal B subtype of breast cancer, suggesting consistency with findings from Western populations.

Article Abstract

Background: Disparities of biomarkers' expression in breast cancer across different races and ethnicities have been well documented. Proline, glutamic acid, and leucine-rich protein 1 (PELP1), a novel ER coregulator, has been considered as a promising biomarker of breast cancer prognosis; however, the pattern of PELP1 expression in Chinese women with breast cancer has never been investigated. This study aims to provide useful reference on possible racial or ethnic differences of PELP1 expression in breast cancer by exploring the pattern of PELP1 expression in Chinese women with primary breast cancer.

Methods: The expression of PELP1 in primary breast cancer samples from 130 Chinese female patients was detected by immunohistochemistry and correlated to other clinicopathological parameters; for comparison, the expression of PELP1 in 26 benign breast fibroadenomas was also examined.

Results: The overall value of the PELP1 H-score in breast cancer was significantly higher than that in breast fibroadenoma (p<0.001). In our breast cancer patients, the ER/HER-2-positive group had significantly higher PELP1 H-scores than their negative counterparts (p=0.003 for ER and p=0.022 for HER-2); the Ki-67-high group also showed significantly higher PELP1 H-scores than the Ki-67-low group (p=0.008). No significant association between PELP1 H-scores and other clinicopathological parameters was found. Finally, the PELP1 H-score in breast cancers of the luminal B subtype was significantly higher than that in the triple negative subtype (p=0.002).

Conclusion: Overexpression of PELP1 in Chinese women with primary breast cancer appears to be associated with biomarkers of poor outcome; these results are similar to other reports based on Western populations.

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Source
http://dx.doi.org/10.5301/jbm.5000078DOI Listing

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