Objective: To investigate the effect of 6-gingerol, the main active component of ginger, on hair shaft elongation in vitro and hair growth in vivo.
Methods: Firstly, Hair follicles were co-cultured with 3 different concentration of 6-gingerol for 5 days and hair elongation in three groups was measured. Secondly, The proliferative effect of 6-gingerol on DPCs was measured using MTT assay. Thirdly, the expression of Bcl-2 and Bax in DPCs were measured using Western blotting. In vivo study, the influence of 6-gingerol on hair growth in C57BL/6 rats was measured through topical application of 6-gingerol on the dorsal skin of each animal.
Results: The length of hair shaft in 20 microg/ml 6-Gingerol group (0.50 +/- 0.08 mm) is less than 0 microg/ml (0.66 +/- 0.19) mm and 10 microg/ml (0.64 +/- 0.03) mm 6-Gingerol group (P < 0.05). In cell culture, compared to 0 microg/ml and 5 microg/ml 6-Gingerol, 10 microg/ml 6-Gingerol can significantly inhibited the proliferation of DPCs (P < 0.05). Along with the growth inhibition of DPCs by 6-gingerol, the Bax/Bcl-2 ratio increased obviously. In vivo study, the hair length and density decreased a lot after using 1 mg/ml 6-gingerol.
Conclusions: 6-Gingerol can suppress human hair shaft elongation because it has pro-apoptotic effects on DPCs via increasing Bax/Bcl-2 ratio. It might inhibit hair growth by prolonging the telogen stage in vivo.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Trichothiodystrophy Identified in a Child with an Odontogenic Infection.
J Dent Child (Chic)
September 2024
Department of Oral and Maxillofacial Surgery, Tufts University School of Dental Medicine, Boston, Mass., USA.
Article Synopsis
- Trichothiodystrophy (TTD) is a rare genetic disorder that presents with brittle hair, photosensitivity, scaly skin, and stunted growth, leading to a high mortality rate in children mainly due to infections.
- A case report highlights a five-year-old boy with these symptoms who was diagnosed with TTD after genetic testing during treatment for a dental infection.
- The report emphasizes the need for comprehensive evaluation of pediatric patients to improve diagnosis and care for genetic disorders like TTD, involving a collaborative approach among healthcare providers.
Videodermoscopy as a Diagnostic Tool for Pili Trianguli and Canaliculi Syndrome.
Pediatr Dermatol
December 2024
Department of Health Sciences, University of Florence, Florence, Italy.
Pili trianguli et canaliculi syndrome is a rare hair shaft disorder characterized by frizzy hair that cannot be smoothed flat. Affected hair shafts are triangular or kidney-shaped with longitudinal grooving. Diagnosis typically requires electron microscopy, which may be cost-prohibitive, or alternatively, the distinctive features of hair shafts can be identified through histological examination of cross sections, that is time-consuming.
View Article and Find Full Text PDFProteomic Analysis of Single Hairs.
Methods Mol Biol
December 2024
University of California - Davis, Department of Environmental Toxicology, Davis, CA, USA.
Hair is a ubiquitous and robust mammalian tissue with biological, clinical, forensic, social, and economic significance. The hair shaft proteome reflects both structural proteins, dominated by cuticular intermediate filament keratins and associated proteins, and proteins involved in the final cellular processes of terminally differentiating corneocytes prior to cornification. These distinct biological processes involve cell maintenance, biosynthesis, senescence, and xenobiotic response.
View Article and Find Full Text PDFDevelopment of in vitro hair pigmentation model using hair follicle organoids.
J Biosci Bioeng
December 2024
Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama, Kanagawa 240-8501, Japan; Kanagawa Institute of Industrial Science and Technology, 3-2-1 Sakado Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan. Electronic address:
Hair color is formed through a series of processes such as melanin synthesis and storage in melanosomes, transfer from melanocytes, and reception by hair matrix cells in the hair bulb. Because gray hair is caused by the deterioration of a single or multiple of these processes, understanding the mechanisms responsible for these processes is crucial for developing therapeutic strategies. Recently, a robust approach for preparing hair follicle organoids (HFOs) was reported, in which hair follicle morphogenesis, including hair shaft elongation, was tracked in vitro.
View Article and Find Full Text PDFIndonesian dreadlock hair: a novel presentation of hair shaft disorders.
Arch Dermatol Res
December 2024
Sinclair Dermatology, East Melbourne, VIC, Australia.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!