These are presented drinking water regulations in Ukraine on microbiological indices in the new state document "Hygienic Drinking water regulations intended for human consumption" (State sanitary regulations and standards (GsanPiN) 2.2.4-171-10). There is reported an analysis of both the open waterbodies water quality and water for centralized water supply in 2007-2011 and 1992-1996 also on sanitary-bacteriological indices for performance of comparative retrospective analysis. There has been shown water quality degradation for open waterbodies, the main sources of water supply for population. Against this background, a marked improvement of drinking water quality has been noted, the number of non-standard samples decreased to 3.6 % compared with 8.8% in the preceding 15 years. This index correlates with a decrease in the number of outbreaks of infections transmitted by water. There was noted unsatisfactory registration of viral infections with water pathway of transmission and the increase in morbidity rate of gastroenterocolitides of unknown etiology that may include acute viral intestinal infections. Expediency to keep "fermentation of glucose" test in bacteriological examination of water in the identification scheme of general coliforms has been substantiated.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Background: Several studies have shown the influential role of nutraceuticals on cognition and mental functions. Dihydroxytrimethoxyflavone, a natural flavone found in herbal drugs, is documented to be neuroprotective in different model systems. Nevertheless, possible memory improvement effects of dihydroxytrimethoxyflavone via nuclear factor-E2-related factor 2 (Nrf2) (a crucial regulator of antioxidative system) has not been systematically evaluated.
View Article and Find Full Text PDFActivation and Reactivity of the Deubiquitinylase OTU Cezanne-2 from MD Simulations and QM/MM Calculations.
J Chem Inf Model
January 2025
Molecular Simulations and Design Group, Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, 39106 Magdeburg, Germany.
Cezanne-2 (Cez2) is a deubiquitinylating (DUB) enzyme involved in the regulation of ubiquitin-driven cellular signaling and selectively targets Lys11-linked polyubiquitin chains. As a representative member of the ovarian tumor (OTU) subfamily DUBs, it performs cysteine proteolytic isopeptide bond cleavage; however, its exact catalytic mechanism is not yet resolved. In this work, we used different computational approaches to get molecular insights into the Cezanne-2 catalytic mechanism.
View Article and Find Full Text PDFClinical implications of mineralocorticoid receptor overactivation.
Clin Kidney J
January 2025
Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
The mineralocorticoid receptor (MR) is a nuclear transcription factor that plays a critical role in regulating fluid, electrolytes, blood pressure, and hemodynamic stability. In conditions such as chronic kidney disease (CKD) and heart failure (HF), MR overactivation leads to increased salt and water retention, inflammatory and fibrotic gene expression, and organ injury. The MR is essential for transcriptional regulation and is implicated in metabolic, proinflammatory, and pro-fibrotic pathways.
View Article and Find Full Text PDF[Protective effect of tumor necrosis factor receptor-associated factor 6 inhibitor C25-140 on acute kidney injury induced by diquat poisoning in mice].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
December 2024
Department of Emergency, Kweichow Moutai Hospital, Renhuai 564500, Guizhou, China. Corresponding author: Ou Renyang, Email:
Objective: To investigate the protective effect and mechanism of tumor necrosis factor receptor-associated factor 6 (TRAF6) inhibitor C25-140 on acute kidney injury (AKI) induced by acute diquat (DQ) poisoning in mice.
Methods: A total of 80 SPF grade healthy male C57BL/6 mice were randomly divided into the normal control group, DQ model group, C25-140 intervention group, and C25-140 control group, with 20 mice in each group. The DQ poisoning mouse model was established by using one-time intraperitoneal injection of 1 mL of 40 mg/kg DQ solution.
Revealing gaps in marine evidence with a natural capital lens.
Philos Trans R Soc Lond B Biol Sci
January 2025
University College London Institute for Sustainable Resources, Central House, 14 Upper Woburn Place, London WC1H 0NN, UK.
The natural capital concept positions the natural environment as an asset, crucial for the flow of goods and benefits to humanity. There is a growing trend in applying this concept in marine environmental management in the United Kingdom (UK). This study evaluates six varied marine decisions across England, Scotland and Wales.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!