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GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding.
Nat Commun
January 2025
National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, People's Republic of China.
The Eurasian avian-like (EA) H1N1 swine influenza virus (SIV) possesses the capacity to instigate the next influenza pandemic, owing to its heightened affinity for the human-type α-2,6 sialic acid (SA) receptor. Nevertheless, the molecular mechanisms underlying the switch in receptor binding preferences of EA H1N1 SIV remain elusive. In this study, we conduct a comprehensive genome-wide CRISPR/Cas9 knockout screen utilizing EA H1N1 SIV in porcine kidney cells.
View Article and Find Full Text PDFInfluenza vaccination hesitancy and related factors among pregnant and breastfeeding women: A cross-sectional study.
Hum Vaccin Immunother
December 2025
Department of Innovative Technologies in Medicine & Dentistry, "G. d'Annunzio" University of Chieti - Pescara, Chieti, Italy.
Achieving safe influenza vaccination coverage among pregnant and breastfeeding women is a global health goal due to the potential risks of serious influenza for both mother and child. However, vaccine hesitancy remains a significant barrier to vaccination uptake. Since anxiety represents a determinant in vaccine decision-making, this study aimed to assess influenza vaccination hesitancy and anxiety levels in this population and to explore the association between women's characteristics, their reluctance, and anxiety levels.
View Article and Find Full Text PDFImproving influenza forecast in the tropics and subtropics: a case study of Hong Kong.
J R Soc Interface
January 2025
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Influenza forecasts could aid public health response as shown for temperate regions, but such efforts are more challenging in the tropics and subtropics due to more irregular influenza activities. Here, we built six forecast approaches for influenza in the (sub)tropics, with six model forms designed to model seasonal infection risk (i.e.
View Article and Find Full Text PDFRisk factors for the incursion of highly pathogenic avian influenza virus into poultry and other captive bird holdings in Denmark from 2020 to 2023: A case-control study.
Prev Vet Med
January 2025
Department of Veterinary and Animal Sciences, University of Copenhagen, Grønnegårdsvej 8, Frederiksberg C 1870, Denmark.
Highly pathogenic avian influenza (HPAI) is a major concern in terms of animal and human health. Between October 2020 and September 2023, there were 36 HPAI outbreaks detected in poultry and other captive birds in Denmark. However, it is often not possible to determine the exact route of introduction.
View Article and Find Full Text PDFMystery flu-like outbreak raises another alarm in Congo: The next disease X?
New Microbes New Infect
February 2025
Department of Paediatrics, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, 411018, Maharashtra, India.
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