AI Article Synopsis
- Understanding cachexia in pancreatic cancer has improved over the last decade, revealing it as a complex syndrome involving significant weight loss and functional decline.
- Treatment remains challenging and requires a multifactorial strategy, addressing both tissue loss and appetite issues.
- The paper discusses current knowledge on its assessment and pathophysiology, emphasizing the need for combined nutritional and pharmaceutical approaches for effective management.
Article Abstract
Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge. Pancreatic cancer cachexia is a multifactorial syndrome characterized by uncompensated adipose tissue and skeletal muscle loss in the setting of anorexia that leads to progressive functional impairment. This paper will review the current concepts of pancreatic cancer cachexia, its assessment and pathophysiology as well as current and future treatments. The successful management of pancreatic cancer cachexia will likely require a multimodal approach that includes nutritional support and combination pharmaceutical interventions.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939686 | PMC |
| http://dx.doi.org/10.3389/fphys.2014.00088 | DOI Listing |
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