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New Markers of Early Kidney Damage in Children and Adolescents with Simple Obesity.
Int J Mol Sci
October 2024
Clinical Department of Paediatric Nephrology, Wroclaw Medical University, 50-367 Wrocław, Poland.
The impact of obesity on kidney injury and the development of chronic kidney disease (CKD) is well documented. Unfortunately, the early stages of CKD are asymptomatic, leading to a delayed diagnosis and a worse prognosis. There is a need for more sensitive indicators of kidney damage than those currently used.
View Article and Find Full Text PDFProteomic Analysis Identifies Dysregulated Proteins in Albuminuria: A South African Pilot Study.
Biology (Basel)
August 2024
Future Production Chemicals, Council for Scientific and Industrial Research, Pretoria 0001, South Africa.
Albuminuria may precede decreases in the glomerular filtration rate (GFR) and both tests are insensitive predictors of early stages of kidney disease. Our aim was to characterise the urinary proteome in black African individuals with albuminuria and well-preserved GFR from South Africa. This case-controlled study compared the urinary proteomes of 52 normoalbuminuric (urine albumin: creatinine ratio (uACR) < 3 mg/mmol) and 56 albuminuric (uACR ≥ 3 mg/mmol) adults of black African ethnicity.
View Article and Find Full Text PDFUrinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.
J Extracell Biol
September 2024
Immunology Department Instituto de Investigación Sanitaria Fundación Jiménez Díaz-UAM Madrid Spain.
Background: Current definition of chronic kidney disease (CKD) identifies only advanced stages, but effective management demands early detection. Urinary albumin-to-creatinine ratio (ACR) 30 mg/g is a cut-off point for CKD clinical diagnosis. Patients with lower values (normoalbuminuria) and eGFR > 60 mL/min/1.
View Article and Find Full Text PDFCan immature granulocytes and neutrophil-lymphocyte ratio be biomarkers to evaluate diabetic nephropathy?: A cross-sectional study.
J Diabetes Complications
September 2024
Nigde Omer Halisdemir University Training and Research Hospital, Clinical Biochemistry Laboratory,Aşağı Kayabaşı Mah. Hastaneler Cad., Kumluca Mevki, 51100 Merkez/Nigde, Turkey; Nigde Omer Halisdemir University, Faculty of Medicine, Department of Medical Biochemistry, Nigde Ömer Halisdemir Üniversitesi Merkez Yerleşkesi, Tıp Fakültesi Bor Yolu Üzeri, 51240 Merkez/Nigde, Turkey.
Aims: We aimed to examine the role of circulating immature granulocytes (IGs) in assessing Diabetic Nephropathy (DN) mainly and also associations of other leukocyte parameters with DN.
Methods: In this retrospective cross-sectional study, a total of 164 Diabetes Mellitus patients were grouped as normoalbuminuric and microalbuminuric according to urinary albumin excretion in the course of admission. Neutrophil-lymphocyte ratio (NLR), IG count (IG#) and IG percentage (IG%) levels were compared between the groups.
Cardiovascular and Kidney Outcomes of Non-Diabetic CKD by Albuminuria Severity: Findings From the CRIC Study.
Am J Kidney Dis
December 2024
Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Article Synopsis
- The study focused on the clinical outcomes of chronic kidney disease (CKD) in non-diabetic patients, particularly how different levels of albuminuria affect kidney and heart health.
- The research included 1,463 adults diagnosed with CKD participating in the Chronic Renal Insufficiency Cohort study, analyzing the impact of albuminuria stages on kidney and cardiovascular events.
- Results indicated that higher albuminuria levels led to significantly worse kidney outcomes and faster declines in kidney function, with individuals having severe albuminuria showing the most rapid deterioration.
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