AI Article Synopsis
- This study investigates the link between microRNA-196a (miR-196a) expression and the classification of intraductal papillary mucinous neoplasms (IPMNs) in the pancreas, focusing on distinguishing intestinal-type from non-intestinal-type IPMNs.
- Researchers analyzed 37 tissue samples and 36 pancreatic juice samples, and found that miR-196a levels were significantly higher in both intestinal-type tissues and pancreatic juices compared to non-intestinal-type.
- The findings suggest that miR-196a can serve as a reliable biomarker for identifying intestinal-type IPMNs, with 83% sensitivity and specificity for predictions based on pancreatic juice analysis.
Article Abstract
Objectives: Aberrant expression of several microRNAs (miRs) has been reported in various neoplasms including intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. MicroRNA-196a (miR-196a) is up-regulated in Barrett esophagus (characterized by intestinal metaplasia) and in colorectal cancer; this relationship between intestinal characteristics and miR-196a might also be applicable to intestinal-type IPMNs. The aim of this study was to evaluate whether intestinal-type IPMNs can be discriminated from non-intestinal-type IPMNs by the expression level of miR-196a in tissue and pancreatic juice samples.
Methods: Thirty-seven formalin-fixed paraffin-embedded tissue samples (including 3 of normal pancreatic ducts) and 36 pancreatic juice samples were obtained. The expression level of miR-196a measured by quantitative reverse transcription-polymerase chain reaction assays was compared between intestinal-type and non-intestinal-type IPMNs.
Results: MicroRNA-196a expression in intestinal-type IPMN tissue samples (n = 18) was significantly higher than that of non-intestinal-type IPMNs (n = 16) (P < 0.001). Similarly, miR-196a expression in pancreatic juice samples of intestinal-type IPMNs (n = 6) was significantly higher than that of non-intestinal-type IPMNs (n = 30) (P = 0.008), and the sensitivity and specificity for prediction of intestinal-type IPMNs using pancreatic juice samples were both 83%.
Conclusions: Elevated expression of miR-196a in pancreatic juice samples is predictive of intestinal-type IPMNs.
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| http://dx.doi.org/10.1097/MPA.0000000000000042 | DOI Listing |
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