Case reports of patients with mal-functioning metal-on-metal hip replacement (MoMHR) prostheses suggest an association of elevated circulating metal levels with visual and auditory dysfunction. However, it is unknown if this is a cumulative exposure effect and the impact of prolonged low level exposure, relevant to the majority of patients with a well-functioning prosthesis, has not been studied. Twenty four male patients with a well-functioning MoMHR and an age and time since surgery matched group of 24 male patients with conventional total hip arthroplasty (THA) underwent clinical and electrophysiological assessment of their visual and auditory health at a mean of ten years after surgery. Median circulating cobalt and chromium concentrations were higher in patients after MoMHR versus those with THA (P<0.0001), but were within the Medicines and Healthcare Products Regulatory Agency (UK) investigation threshold. Subjective auditory tests including pure tone audiometric and speech discrimination findings were similar between groups (P>0.05). Objective assessments, including amplitude and signal-to-noise ratio of transient evoked and distortion product oto-acoustic emissions (TEOAE and DPOAE, respectively), were similar for all the frequencies tested (P>0.05). Auditory brainstem responses (ABR) and cortical evoked response audiometry (ACR) were also similar between groups (P>0.05). Ophthalmological evaluations, including self-reported visual function by visual functioning questionnaire, as well as binocular low contrast visual acuity and colour vision were similar between groups (P>0.05). Retinal nerve fibre layer thickness and macular volume measured by optical coherence tomography were also similar between groups (P>0.05). In the presence of moderately elevated metal levels associated with well-functioning implants, MoMHR exposure does not associate with clinically demonstrable visual or auditory dysfunction.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951221 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090838 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Advancements in Smart Wearable Mobility Aids for Visual Impairments: A Bibliometric Narrative Review.
Sensors (Basel)
December 2024
Department of Industrial Design, Guangdong University of Technology, Guangzhou 510006, China.
Research into new solutions for wearable assistive devices for the visually impaired is an important area of assistive technology (AT). This plays a crucial role in improving the functionality and independence of the visually impaired, helping them to participate fully in their daily lives and in various community activities. This study presents a bibliometric analysis of the literature published over the last decade on wearable assistive devices for the visually impaired, retrieved from the Web of Science Core Collection (WoSCC) using CiteSpace, to provide an overview of the current state of research, trends, and hotspots in the field.
View Article and Find Full Text PDFNuances of an In-Between Space of Learning Through Auditory Approaches in Early Piano Instruction.
Behav Sci (Basel)
November 2024
Nanyang Academy of Fine Arts, University of the Arts Singapore, Singapore 189655, Singapore.
Musical experiences in early piano instruction tend to be led by visual-based methods, limiting opportunities to develop aural abilities for children to understand music. This study examines the exploratory behaviour of music listening through auditory approaches that support visual-based methods to foster musical comprehension. Drawing from case studies of young music learners between the ages of 7 and 8, qualitative data were collected through lesson observations, interviews, game-based assessments, and performance evaluations of a prepared piece.
View Article and Find Full Text PDFRecent work has claimed that most apparently cross-modal responses in sensory cortex are instead caused by the face movements evoked by stimuli of the non-dominant modality. We show that visual stimuli rarely trigger face movements in awake mice; when they occur, such movements do not explain visual responses in auditory cortex; and in simultaneous recordings, face movements drove artifactual cross-modal responses in visual but not auditory cortex. Thus face movements do not broadly explain cross-modal activity across all stimulus modalities.
View Article and Find Full Text PDFBackground: Converging evidence from clinical neuroimaging and animal models has strongly implicated dysfunction of thalamocortical circuits in the pathophysiology of schizophrenia. Preclinical models of genetic risk for schizophrenia have shown reduced synaptic transmission from auditory thalamus to primary auditory cortex, which may represent a correlate of auditory disturbances such as hallucinations. Human neuroimaging studies, however, have found a generalized increase in resting state functional connectivity (RSFC) between whole thalamus and sensorimotor cortex in people with schizophrenia (PSZ).
View Article and Find Full Text PDFAberrant controllability of functional connectome during working memory tasks in patients with schizophrenia and unaffected siblings.
Br J Psychiatry
January 2025
Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Canada.
Background: Working memory deficit, a key feature of schizophrenia, is a heritable trait shared with unaffected siblings. It can be attributed to dysregulation in transitions from one brain state to another.
Aims: Using network control theory, we evaluate if defective brain state transitions underlie working memory deficits in schizophrenia.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!