Bioconjug Chem
Princess Margaret Cancer Centre and Techna Institute, University Health Network, Toronto, Ontario M5G1L7, Canada.
Published: April 2014
Microbubbles (MBs) are currently used as ultrasound (US) contrast agents and as delivery vehicles for site-specific US-triggered drug and gene delivery. Multimodal US-based imaging methods have been applied preclinically to assess and validate the effectiveness and fate of MBs in imaging and therapy. Here we present the first intrinsically trimodal MBs by incorporating a dense concentration of porphyrin molecules within a MB shell, enabled by the use of a single porphyrin-lipid component. These MBs possess US, photoacoustic, and fluorescence properties that are demonstrated in solution and in a mouse tumor xenograft model. They also have potential to be extended to other imaging modalities such as magnetic resonance imaging and nuclear imaging.
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http://dx.doi.org/10.1021/bc5000725 | DOI Listing |
Adv Healthc Mater
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Department of Ultrasound, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
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College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan, 250014, P. R. China.
Cancer is one of the leading causes of death worldwide, posing a significant threat to human health. Although immunotherapy has shown promise in cancer treatment, its efficacy is often compromised by tumor immune evasion, which hinders treatment outcomes. Therefore, combining immunotherapy with other therapeutic approaches to enhance its effectiveness has become an increasingly accepted strategy in clinical practice.
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Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Precise and effective management of myocardial ischemia/reperfusion injury (MIRI) is still a formidable challenge in clinical practice. Additionally, real-time monitoring of drug aggregation in the MIRI region remains an open question. Herein, a drug delivery system, hesperadin and ICG assembled in PLGA-Se-Se-PEG-IMTP (HI@PSeP-IMTP), is designed to deliver hesperadin and ICG to the MIRI region for in vivo optical imaging tracking and to ameliorate MIRI.
View Article and Find Full Text PDFAdv Healthc Mater
January 2025
Center for Molecular Systems and Organic Devices (CMSOD), Key Laboratory for Organic Electronics & Information Displays (KLOEID) and Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications (NJUPT), Nanjing, 210023, China.
Organic photosensitizers (PSs) possessing NIR-II emission and photodynamic/photothermal effect have received a great sense of attention for their cutting-edge applications in imaging-guided multimodal phototherapy. However, it is highly challenging to design efficient PSs with high luminescence and phototherapy performance simultaneously. In this study, a spiro-functionalization strategy is proposed to alleviate aggregate-caused quenching of PSs and promote photodynamic therapy, and the strategy is verified via a spiro[fluorine-9,9'-xanthene]-modified NIR-II PS (named SFX-IC) with an acceptor-donor-acceptor configuration.
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January 2025
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Intracranial optical imaging of glioblastoma (GBM) is challenging due to the scarcity of effective probes with blood-brain barrier (BBB) permeability and sufficient imaging depth. Herein, we describe a rational strategy for designing optical probes crossing the BBB based on an electron donor-π-acceptor system to adjust the lipid/water partition coefficient and molecular weight of probes. The amphiphilic hemicyanine dye (namely, IVTPO), which exhibits remarkable optical properties and effective BBB permeability, is chosen as an efficient fluorescence/photoacoustic probe for in vivo real-time imaging of orthotopic GBM with high resolution through the intact skull.
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