AI Article Synopsis
Article Abstract
Objective: To evaluate the prognostic value of the cortical N-acetyl aspartate to creatine ratio (NAA/Cr) in early relapsing-remitting multiple sclerosis (RRMS).
Methods: Sixteen patients with newly diagnosed RRMS were studied by serial MRI and MR spectroscopic imaging (MRSI) once every 6 months for 24 months. Clinical examinations, including the expanded disability status scale (EDSS), were performed at baseline, month 24, and at year 7.
Results: Baseline cortical NAA/Cr correlated inversely with EDSS at month 24 (r = -0·61, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline cortical NAA/Cr also correlated inversely with EDSS at the 7-year follow-up (r = -0·56, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline brain parenchymal fraction (BPF) correlated inversely with EDSS at month 24 (r = -0·61, P < 0·05), but not with EDSS at year 7.
Discussion: Cortical NAA/Cr in early RRMS correlated with clinical disability after 2 and 7 years and may be used as a predictor of long-term disease outcome.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1179/1743132813Y.0000000312 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gender differences of neurometabolic and neuroendocrine alternations and its lateralization in adolescents with major depressive disorder.
BMC Psychiatry
December 2024
Department of Psychiatry, First Affiliated Hospital, Jinan University, Guangzhou, 510630, China.
Background: The clinical characteristics of major depressive disorder (MDD) in adolescents show notable gender-related differences, but the cause of these differences is still not understood. The current research concentrates on the changes in neurometabolism and neuroendocrine function, aiming to identify differences in endocrine function and brain metabolism between male and female adolescents with MDD.
Methods: A total of 121 teenagers diagnosed with MDD (43 males and 78 females) were enlisted as participants.
MRI graph parameters are longitudinal markers of neuronal integrity in multiple sclerosis.
Mult Scler Relat Disord
October 2023
Ottawa Hospital, Department of Medical Imaging; University of Ottawa, Department of Radiology, Radiation Oncology and Medical Physics; University of Ottawa, Brain and Mind Research Institute. Electronic address:
Article Synopsis
- - The study aimed to see if structural network parameters provide additional insights into the effectiveness of MS treatment after immunoablation and autologous stem cell transplantation, focusing on patients whose relapses were suppressed.
- - Researchers analyzed data from 24 MS patients before and after treatment, assessing brain health markers like N-acetylaspartate to creatine ratio (NAA/Cr) and serum neurofilament light chain (sNfL) in relation to network parameters.
- - Results showed that changes in network parameters post-treatment were significantly linked to improved measures of neuronal injury, suggesting these parameters could serve as valuable indicators of disease severity in progressive MS.
Understanding the potential mechanisms of disease modifying effects of physical activity and exercise in people with schizophrenia.
Schizophr Res
December 2024
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China. Electronic address:
Schizophrenia is a serious chronic mental health problem that usually starts during adolescence and early childhood. It is characterized by positive symptoms (delusions, hallucinations and grossly disorganized speech and behaviour), negative symptoms (apathy, isolation and diminished affect), and cognitive impairment that negatively affect quality of life. Its treatments include the use of pharmacological interventions, exercise, non-invasive brain stimulation and cognitive remediation training.
View Article and Find Full Text PDFChanges in the medial prefrontal cortex metabolites after 6 months of medication therapy for patients with bipolar disorder: A H-MRS study.
CNS Neurosci Ther
September 2024
Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Article Synopsis
- The study investigated brain metabolite differences in the medial prefrontal cortex (mPFC) of individuals with bipolar disorder (BD) during acute and euthymic episodes over a 6-month medication treatment period.
- Using H-MRS technology, researchers compared metabolite levels in 53 BD patients (32 in depressive phase, 21 in manic phase) and 34 healthy controls at baseline, then followed up with 40 subjects after treatment.
- Results showed significant reductions in N-acetyl aspartate (NAA) in both depressive and manic episodes compared to healthy controls, and a notable decrease in glutamine (Gln) levels in the manic group after 6 months, suggesting that these metabolites may serve as
Challenges with hippocampal MR spectroscopy as a surrogate for pre-radiotherapy assessment of neurocognitive impairment in patients with brain metastasis.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
September 2024
Research Center for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Aim: Patients with multiple brain metastases (BM) benefit from hippocampal-avoiding whole brain radiotherapy (HA-WBRT), the challenging and less available form of WBRT. This study explores potential of pre-radiotherapy (pre-RT) hippocampal magnetic resonance spectroscopy (MRS) measuring hippocampal neuronal density as an imaging surrogate and predictive tool for assessing neurocognitive functions (NCF).
Methods: 43 BM patients underwent pre-RT hippocampal MRS.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!