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Setting up multicolour TIRF microscopy down to the single molecule level.
Biomol Concepts
January 2023
NEST Laboratory, Scuola Normale Superiore, Piazza San Silvestro 12, I-56127, Pisa, Italy.
Investigating biological mechanisms in ever greater detail requires continuous advances in microscopy techniques and setups. Total internal reflection fluorescence (TIRF) microscopy is a well-established technique for visualizing processes on the cell membrane. TIRF allows studies down to the single molecule level, mainly in single-colour applications.
View Article and Find Full Text PDFHarmonizing the growing fluorogenic RNA aptamer toolbox for RNA detection and imaging.
Chem Soc Rev
June 2023
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
The field of fluorogenic RNA aptamers is a burgeoning research area that aims to address the lack of naturally fluorescent RNA molecules for RNA detection and imaging. These small RNA tags bind to their fluorogenic ligands resulting in significant fluorescent enhancement, leading to a molar brightness comparable to or exceeding that of fluorescent proteins. In the past decade, multiple light-up RNA aptamer systems have been isolated that bind to a broad range of ligands involving several distinct mechanisms of fluorogenicity.
View Article and Find Full Text PDFDiagnosis and treatment of nail melanoma: a review of the clinicopathologic, dermoscopic, and genetic characteristics.
J Eur Acad Dermatol Venereol
May 2022
Department of Dermatology, Samsung Medical Center Sungkyunkwan University, Seoul, Korea.
Nail melanoma (NM) is an important differential diagnosis in patients with longitudinal melanonychia. However, diagnosis is often challenging as it is difficult to differentiate from other pigmented nail disorders. The main challenge for diagnosis is obtaining adequate nail matrix biopsy specimens for histopathological assessment.
View Article and Find Full Text PDFDefect-related multicolour emissions in ZnO smoke: from violet, over green to yellow.
Nanoscale
March 2019
Sorbonne Université, CNRS, Laboratoire de Réactivité de Surface, LRS, F-75005 Paris, France.
The nature of defects in ZnO smoke was studied at different stages of the material's history by combining photoluminescence (PL) and electron paramagnetic resonance (EPR) spectroscopy. In contrast to studies previously reported on ZnO nanopowders, high vacuum conditions (P < 10-5 mbar) have been applied during sample storage, handling and spectroscopic investigations. Two pairs of violet-PL/EPR signals (2.
View Article and Find Full Text PDFDiagnosis of Paroxysmal Nocturnal Hemoglobinuria: Recent Advances.
Indian J Hematol Blood Transfus
December 2017
Department of Hematology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder with its protean clinical manifestations. This is due to partial or complete absence of 'glycophosphatidyl-inositol-anchor proteins' (GPI-AP). The main aim of this review is to highlight various diagnostic modalities available, basic principle of each test and recent advances in the diagnosis of PNH.
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