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Epitranscriptomic RNA mA Modification in Cancer Therapy Resistance: Challenges and Unrealized Opportunities.
Adv Sci (Weinh)
December 2024
Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, 11794, USA.
Significant advances in the development of new cancer therapies have given rise to multiple novel therapeutic options in chemotherapy, radiotherapy, immunotherapy, and targeted therapies. Although the development of resistance is often reported along with temporary disease remission, there is often tumor recurrence of an even more aggressive nature. Resistance to currently available anticancer drugs results in poor overall and disease-free survival rates for cancer patients.
View Article and Find Full Text PDFSequencing historical RNA: unrealized potential to increase understanding of the plant tree of life.
Trends Plant Sci
November 2024
Department of Biological Sciences, The University of Illinois at Chicago, Chicago, IL 60607, USA. Electronic address:
Recent studies have demonstrated that it is a misconception that transcriptome sequencing requires tissue preserved at ultracold temperatures. Here, we outline the potential origins of this misconception and its possible role in biasing the geographic distribution of published plant transcriptomes. We highlight the importance of ensuring diverse sampling by providing an overview of the questions that transcriptomes can answer about the forces shaping the plant tree of life.
View Article and Find Full Text PDFDetecting and Controlling DNA Translocation through a Nanopore using a van der Waals Heterojunction Diode.
Res Sq
November 2024
Holonyak Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States.
A long-unrealized goal in solid-state nanopore sensing is to achieve out-of-plane electrical sensing and control of DNA during translocation, which is a prerequisite for base-by-base ratcheting that enables DNA sequencing in biological nanopores. Two-dimensional (2D) heterostructures, with their capability to construct out-of-plane electronics with atomic layer precision, are ideal yet unexplored candidates for use as electrical sensing membranes. Here we demonstrate a nanopore architecture using a vertical 2D heterojunction diode consisting of p-type WSe on n-type MoS.
View Article and Find Full Text PDFAn Opportunity for Developing Cancer Prevention Leadership in Mexico.
J Cancer Educ
October 2024
Cancer Prevention Research Training Program and Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 77230, USA.
Cancer in Mexico is a major public burden for which rates are expected to increase over time. In settings like Mexico, much potential for reduction through cancer prevention efforts remains unrealized, due in part, to a lack of formal cancer prevention and control training and career opportunities. We trained a cadre of instructors to deliver a pilot cancer prevention education program for oncology professionals and leaders.
View Article and Find Full Text PDFDark diversity of Odonata in Amazonian streams.
Sci Total Environ
December 2024
Laboratorio de Ecologia e Taxonomia de Invertebrados Aquaticos-LETIA, Instituto de Ciências e Technologia das Águas, Universidade Federal do Oeste do Pará-UFOPA, Campus Tapajós, Vera Paz, sn, block 11, sala 03, Salé, Santarém, Pará, Brasil.
The biological diversity of a region may not be fully sampled due to the low abundance or rarity of species, or the absence of species determined by their niche specificity. Investigating these species is essential for understanding the unrealized ecological potential in different habitats, identifying gaps in local and regional communities, and gaining a better understanding of the impacts of environmental changes. Therefore, to expand knowledge about the diversity of Odonata in Eastern Amazonia considering the absent species, we tested the hypotheses that: 1) Environmental variables will influence dark diversity, with greater explanation by canopy cover where sites with lower canopy cover will have higher dark diversity values, and; 2) Functional traits associated with better species dispersal will be correlated with low dark diversity of Odonata, such as larger and wider wings for example.
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