AI Article Synopsis
- A new method using N-iodosuccinimide (NIS) promotes the reaction between aromatic nucleophiles and N-acylimines made on-site from α-amidosulfides.
- This reaction allows for quick and efficient production of highly functionalized amines.
- The technique is noted for being mild, fast, and complementary to existing methods.
Article Abstract
A general and practical N-iodosuccinimide (NIS)-promoted aza-Friedel-Crafts reaction of various aromatic nucleophiles with N-acylimines generated in situ from α-amidosulfides to give a rapid access to highly functionalized amines is described. The newly developed methodology is very mild, fast, efficient, and complementary.
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| http://dx.doi.org/10.1002/chem.201400117 | DOI Listing |
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