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The End of Race-Conscious Admissions: Why Sealing the Leaky Pathway in Academic Surgery is More Urgent than Ever.
Ann Surg
August 2024
Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Nanocarriers' repartitioning of drugs between blood subcompartments as a mechanism of improving pharmacokinetics, safety, and efficacy.
J Control Release
October 2024
Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:
For medical emergencies, such as acute ischemic stroke, rapid drug delivery to the target site is essential. For many small molecule drugs, this goal is unachievable due to poor solubility that prevents intravenous administration, and less obviously, by extensive partitioning to plasma proteins and red blood cells (RBCs), which greatly slows delivery to the target. Here we study these effects and how they can be solved by loading into nanoscale drug carriers.
View Article and Find Full Text PDFSterically Hindered Oleogel-Based Underwater Adhesive Enabled by Mesh-Tailoring Strategy.
Adv Mater
July 2024
Faculty of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640, P. R. China.
Underwater adhesives hold significant relevance in daily life and numerous industrial applications. Despite considerable efforts, developing scalable, high-performance underwater adhesives through a simple and effective method remains a formidable challenge. This study presents a novel mesh-tailoring strategy for in situ, rapid, and ultrastrong oleogel-based underwater adhesives (OUA), which comprises a highly crosslinked polyurethane network with a matching mesh size (≈2.
View Article and Find Full Text PDFComparison of Laryngeal Mask Airway Seal Between Anesthesiologists and Individuals Without Previous Airway Experience.
J Emerg Med
April 2024
Department of Anesthesiology, Intensive Care, Emergency Medicine and Pain Therapy, Bundeswehr Hospital Ulm, Ulm, Germany; Medical Service, Police Baden-Württemberg, Stuttgart, Germany.
Background: Tracheal intubation is the gold standard for airway management in emergency medicine, but more difficult to apply for inexperienced individuals than laryngeal mask airway (LMA).
Objective: The aim of our study was to investigate if inexperienced individuals are able to secure the airway with the help of LMA after a short introduction. A second aim was to evaluate Thiel-fixed specimens against unfixed ones.
Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency.
Neurobiol Dis
September 2023
University Hospital Würzburg, Center for Interdisciplinary Pain Medicine, Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, 97080 Würzburg, Germany. Electronic address:
Background: The blood-nerve and myelin barrier shield peripheral neurons and their axons. These barriers are sealed by tight junction proteins, which control the passage of potentially noxious molecules including proinflammatory cytokines via paracellular pathways. Peripheral nerve barrier breakdown occurs in various neuropathies, such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and traumatic neuropathy.
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