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Zinc Toxicity: Understanding the Limits.
Molecules
July 2024
Institute of Immunology, Medical Faculty, RWTH Aachen University, Pauwelstrasse 30, 52074 Aachen, Germany.
Zinc, a vital trace element, holds significant importance in numerous physiological processes within the body. It participates in over 300 enzymatic reactions, metabolic functions, regulation of gene expression, apoptosis and immune modulation, thereby demonstrating its essential role in maintaining overall health and well-being. While zinc deficiency is associated with significant health risks, an excess of this trace element can also lead to harmful effects.
View Article and Find Full Text PDFZinc-Containing Over-The-Counter Product Causing Sideroblastic Anemia and Neutropenia.
Cureus
May 2024
Hematology and Oncology, Louisiana State University School of Medicine, New Orleans, USA.
Sideroblastic anemia is characterized by anemia, granulocytopenia, and bone marrow findings of vacuolated precursors and ringed sideroblasts. Zinc-induced copper deficiency can present as sideroblastic anemia and neutropenia. We report the case of a previously healthy 74-year-old female who presented with newly discovered sideroblastic anemia as a result of an over-the-counter oral vitamin and mineral supplement.
View Article and Find Full Text PDFGlycyl-l-histidyl-l-lysine prevents copper- and zinc-induced protein aggregation and central nervous system cell death in vitro.
Metallomics
May 2024
Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, S-171 76 Stockholm, Sweden.
Article Synopsis
- Neurodegenerative diseases often involve oxidative stress, inflammation, and protein misfolding, with copper and zinc being particularly impactful in these processes.
- The tripeptide glycyl-l-histidyl-l-lysine (GHK) can bind to copper, reduce its harmful effects, and prevent cell death caused by copper and zinc in laboratory settings.
- GHK shows promise as a protective compound that can improve protein solubility and prevent aggregation, suggesting its potential use in treating neurodegenerative diseases related to metal toxicity.
Zinc-Induced Copper Deficiency as a Rare Cause of Neurological Deficit and Anemia.
Cureus
August 2023
Family Medicine, Conway Medical Center, Conway, USA.
Upper respiratory infections (URIs) are common and carry a large economic burden due to missed work and school. This has prompted an increased interest in over-the-counter zinc supplementation to enhance immunity and reduce illness duration. Zinc's antiviral and anti-inflammatory effects have led to its inclusion in popular URI medications and a surge in supplement sales, particularly among the elderly.
View Article and Find Full Text PDFIatrogenic copper deficiency: Risks and cautions with zinc prescribing.
Br J Clin Pharmacol
September 2023
Institute of Pharmacy and Biomedical Sciences, Strathclyde University, Glasgow, UK.
Aims: Copper deficiency resulting from prescribing zinc in high doses is a rare but life-changing diagnosis that is frequently overlooked. The aim of this study is to gauge how often zinc-induced copper deficiency is missed, to raise awareness of the condition and to stress the need for guidelines for prescribing zinc.
Methods: Suspected cases of zinc-induced copper deficiency were retrospectively obtained by selecting those patients with hyperzincaemia and hypocupraemia from the database of the Scottish Trace Element Laboratory.
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