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Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057. | LitMetric

Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057.

Bioorg Med Chem Lett

Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 363-883, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, 217 Gajunro, Yuseong-gu, Daejeon 305-333, Republic of Korea. Electronic address:

Published: April 2014

AI Article Synopsis

Article Abstract

Three new pyrrolobenzodiazepine derivatives, boseongazepines A-C (1-3), were isolated from a culture broth of Streptomyces sp. 11A057, together with the known compound usabamycin B (4). The structures of 1-4 were determined through the analysis of spectroscopic data including extensive 1D-, 2D-NMR, and MS techniques. Cell growth inhibition effects of these compounds were evaluated against Jurkat, K-562, HL-60, and HepG2 cell lines.

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Source
http://dx.doi.org/10.1016/j.bmcl.2014.02.022DOI Listing

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