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A descriptive analysis of functional impairments and patho-anatomical findings in eight powerlifters.
J Sports Med Phys Fitness
April 2020
Department of Community Medicine and Rehabilitation, Umea University, Umeå, Sweden -
Background: Low back pain (LBP) is a common pain problem in powerlifters. There is a lack of evidence to guide powerlifters and health-care professionals in understanding the role of powerlifting in the development of LBP and treatment of injuries in powerlifters. This study aimed to describe functional impairments and patho-anatomical findings in eight powerlifters with and without LBP.
View Article and Find Full Text PDFSHADES of grey - The challenge of 'grumbling' cauda equina symptoms in older adults with lumbar spinal stenosis.
Musculoskelet Sci Pract
February 2020
Bolton Foundation Trust, UK.
Diagnosing cauda equina syndrome is challenging in older adults with lumbar spinal stenosis. Understanding these challenges is vital for clinicians who are faced with difficult decisions about when to refer for investigation or surgical management. This is a growing clinical issue because of the escalating prevalence of lumbar spinal stenosis in our ageing population, and increasing demands on healthcare services including imaging and surgical services.
View Article and Find Full Text PDFA randomized clinical trial of early invasive intervention for atrial fibrillation (EARLY-AF) - methods and rationale.
Am Heart J
December 2018
Southlake Regional Health Center, University of Toronto, Newmarket, Canada.
Background: The ideal management of patients with newly diagnosed symptomatic atrial fibrillation (AF) remains unknown. Current practice guidelines recommend a trial of antiarrhythmic drugs (AAD) prior to considering an invasive ablation procedure. However, earlier ablation offers an opportunity to halt the progressive patho-anatomical changes associated with AF, as well as impart other important clinical benefits.
View Article and Find Full Text PDFClinical classification in low back pain: best-evidence diagnostic rules based on systematic reviews.
BMC Musculoskelet Disord
May 2017
Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Background: Clinical examination findings are used in primary care to give an initial diagnosis to patients with low back pain and related leg symptoms. The purpose of this study was to develop best evidence Clinical Diagnostic Rules (CDR] for the identification of the most common patho-anatomical disorders in the lumbar spine; i.e.
View Article and Find Full Text PDFUncovering precision phenotype-biomarker associations in traumatic brain injury using topological data analysis.
PLoS One
August 2017
Brain and Spinal Injury Center (BASIC), Zuckerberg San Francisco General Hospital, San Francisco, CA, United States of America.
Background: Traumatic brain injury (TBI) is a complex disorder that is traditionally stratified based on clinical signs and symptoms. Recent imaging and molecular biomarker innovations provide unprecedented opportunities for improved TBI precision medicine, incorporating patho-anatomical and molecular mechanisms. Complete integration of these diverse data for TBI diagnosis and patient stratification remains an unmet challenge.
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