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Introduction And Aims: We investigated the Australian public's understandings of addiction to alcohol and heroin and the factors predicting support for the idea that these types of addiction are 'diseases' and specifically 'brain diseases'.
Design And Methods: Data were collected as part of the 2012 Queensland Social Survey, a computer-assisted telephone interview of 1263 residents of Queensland, Australia. Participants were presented with scenarios of two addicted persons, one who was addicted to heroin and the other addicted to alcohol. Participants were asked a series of questions about different definitions and causes of addiction for both characters.
Results: Over half of the respondents thought that addiction is a disease (alcohol: 67%, heroin: 53%), but fewer (alcohol: 34%, heroin: 33%) believed that addiction is a brain disease. Belief that addiction has biological causes predicted agreement that addiction is a disease [alcohol: odds ratio (OR) = 3.05 (2.15-4.31), heroin: OR = 3.99 (2.82-5.65)] and a brain disease [alcohol: OR = 4.97 (3.42-7.22), heroin: OR = 14.12 (9.23-21.61)]. Women were more likely than men to agree that addiction is a disease [alcohol: OR = 1.79 (1.35-2.38), heroin: OR = 1.40 (1.09-1.81)] as were those 35 years of age and older [alcohol: OR = 2.25 (1.50-3.40), heroin: OR = 1.50 (1.01-2.24)].
Discussion And Conclusions: There is more public support for the idea that addiction is a 'disease' than for the more specific claim that it is a 'brain disease'. Support for a biological aetiology of addiction predicted higher levels of agreement with both disease concepts.
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http://dx.doi.org/10.1111/dar.12115 | DOI Listing |
CNS Neurosci Ther
December 2024
Department of Functional Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Aims: Cognitive functions are reduced in Parkinson's disease (PD) patients after deep brain stimulation (DBS) surgery. However, the underlying mechanisms remain unclear. The current study attempted to elucidate whether DBS alters the functional connectivity (FC) pattern of cognitive networks in PD patients.
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December 2024
7T Magnetic Resonance Imaging Translational Medical Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Aims: The aim of this study was to investigate the whole-brain asymmetry changes in spinocerebellar ataxia type 3 (SCA3) and their association with movement disorders.
Methods: Voxel-based morphometry (VBM) was used to assess asymmetry in gray matter (GM) volume in 83 genetically confirmed SCA3 patients and 83 sex- and age-matched healthy controls (HCs). The asymmetry index (AI) was analyzed for partial correlation with disease severity, as measured by the Scale for Assessment and Rating of Ataxia (SARA) and International Cooperative Ataxia Rating Scale (ICARS).
CNS Neurosci Ther
December 2024
The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Background: Previous research has demonstrated correlations between the complex types and functions of brain cells and the etiology of glioma. However, the causal relationship between gene expression regulation in specific brain cell types and glioma risk, along with its therapeutic implications, remains underexplored.
Methods: Utilizing brain cell type-specific cis-expression quantitative trait loci (cis-eQTLs) and glioma genome-wide association study (GWAS) datasets in conjunction with Mendelian randomization (MR) and colocalization analyses, we conducted a systematic investigation to determine whether an association exists between the gene expression of specific brain cell types and the susceptibility to glioma, including its subtypes.
JMIRx Med
December 2024
Connected Minds: Neural and Machine Systems for a Healthy, Just Society, York University, Toronto, ON, Canada.
Background: Dance has emerged as a complementary treatment that may promote adaptive neural plasticity while improving symptoms of Parkinson disease (PD), such as balance, gait, posture, and walking. Understanding brain changes that arise from participation in dance interventions is important as these neural plastic changes play an important role in protecting and healing the brain. Although dance has been shown to improve PD motor and nonmotor symptoms, the neural mechanisms underlying these changes, specifically depression and mood, remain elusive.
View Article and Find Full Text PDFCurr Neurol Neurosci Rep
December 2024
The NABI institute, Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Purpose Of Review: Early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (SAH) is the most influential clinical determinant of outcomes. Despite significant advances in understanding of the pathophysiology of EBI, currently no treatments to target EBI have been developed. This review summarizes recent advances in EBI research over the past five years with a focus on potential therapeutic targets.
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