A wide range of applications and research has been done with genome-scale metabolic models. In this work, we describe an innovative methodology for comparing metabolic networks constructed from genome-scale metabolic models and how to apply this comparison in order to infer evolutionary distances between different organisms. Our methodology allows a quantification of the metabolic differences between different species from a broad range of families and even kingdoms. This quantification is then applied in order to reconstruct phylogenetic trees for sets of various organisms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082356 | PMC |
| http://dx.doi.org/10.1089/cmb.2013.0150 | DOI Listing |
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