An immunochemical study of normal prostatic tissue, adenoma and cancer identified the following five antigens: alpha 2-ferroprotein, tissue gamma-esterase, lactoferrin, acidic phosphatase and prostatic beta-globulin. The two latter proteins proved organo-specific prostatic antigens. Levels of all the proteins were measured in normal, adenoma and cancer tissues. A sharp drop in the concentration of organospecific proteins was observed in tumor tissue. The study established a relationship between the level of organospecific proteins and cell differentiation of cancer, which was particularly pronounced for beta-globulin.
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