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Dermatological manifestations during Dengue, Chikungunya, and Zika infections.
Curr Opin Infect Dis
November 2024
Dermatology Unit & Scientific Directorate, Galliera Hospital, Genoa, Italy.
Purpose Of Review: Arboviral infections caused by Dengue, Zika, and Chikungunya viruses continue to pose a significant global health threat, particularly in endemic regions. This review is timely because of the increasing prevalence of these infections, driven by factors such as urbanization and climate change. Dermatological manifestations of these viruses are crucial for early diagnosis, especially given the overlap in symptoms, which can complicate differential diagnosis.
View Article and Find Full Text PDFCorrelation of Geographic Variables with the Incidence Rate of Dengue Fever in Mexico: A 38-Year Study.
Microorganisms
December 2024
Coordination of Health Research, Mexican Institute of Social Security, Mexico City 06720, Mexico.
Background: Dengue is a viral disease transmitted by the mosquitoes , which is characterized by fever, myalgia and arthralgia. In some cases, it can be fatal. For many years, dengue fever has been endemic to Mexico; however, few studies have investigated the historical and current extents of dengue fever at the national level or considered the effects of variables such as temperature, precipitation and elevation on its occurrence.
View Article and Find Full Text PDFDifferential Transcriptional Landscape of Vero Cells During Dengue Virus 2 Infection in the Presence of Sinococuline.
Microorganisms
December 2024
Translational Health, Molecular Medicine Division, International Centre for Genetic Engineering & Biotechnology, New Delhi 110067, India.
Dengue virus (DENV) is transmitted by genus mosquitoes and is responsible for dengue fever (DF) and other severe diseases, posing a significant challenge to the global health system. Currently, anti-dengue pharmacological treatment options are not available. Earlier, we demonstrated that Sinococuline has potent anti-dengue activity and prevents virus infection.
View Article and Find Full Text PDFDetrimental Effects of Anti-Nucleocapsid Antibodies in SARS-CoV-2 Infection, Reinfection, and the Post-Acute Sequelae of COVID-19.
Pathogens
December 2024
Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Suita 565-0871, Japan.
Antibody-dependent enhancement (ADE) is a phenomenon in which antibodies enhance subsequent viral infections rather than preventing them. Sub-optimal levels of neutralizing antibodies in individuals infected with dengue virus are known to be associated with severe disease upon reinfection with a different dengue virus serotype. For Severe Acute Respiratory Syndrome Coronavirus type-2 infection, three types of ADE have been proposed: (1) Fc receptor-dependent ADE of infection in cells expressing Fc receptors, such as macrophages by anti-spike antibodies, (2) Fc receptor-independent ADE of infection in epithelial cells by anti-spike antibodies, and (3) Fc receptor-dependent ADE of cytokine production in cells expressing Fc receptors, such as macrophages by anti-nucleocapsid antibodies.
View Article and Find Full Text PDFDENV-1 Infection of Macrophages Induces Pyroptosis and Causes Changes in MicroRNA Expression Profiles.
Biomedicines
November 2024
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
Background: Dengue virus (DENV) is the most widespread mosquito-borne virus, which can cause dengue fever with mild symptoms, or progress to fatal dengue hemorrhagic fever and dengue shock syndrome. As the main target cells of DENV, macrophages are responsible for the innate immune response against the virus.
Methods: In this study, we investigated the role of pyroptosis in the pathogenic mechanism of dengue fever by examining the level of pyroptosis in DENV-1-infected macrophages and further screened differentially expressed microRNAs by high-throughput sequencing to predict microRNAs that could affect the pyroptosis of the macrophage.
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