AI Article Synopsis
- The study investigated the levels of beta-nerve growth factor (NGF) mRNA in the submandibular gland of mice through in situ hybridization.
- The research included both male and female mice at various ages (3 to 12 weeks), revealing NGF mRNA present in all groups but significantly increased after 5 weeks.
- A notable difference was observed between sexes, with male mice showing a marked increase in NGF mRNA as their granular convoluted tubules developed, particularly at 6 to 12 weeks.
Article Abstract
We studied the presence of beta-nerve growth factor (NGF) mRNA in the submandibular gland of the mouse by in situ hybridization using 35S-labeled prepro-beta-NGF antisense RNA. Female and male mice were studied at different stages of postnatal development, ranging from 3 to 12 weeks. Although NGF mRNA was detectable in the granular convoluted tubules of the submandibular gland in all the age and sex groups studied, the abundance of the signal dramatically increased after 5 weeks during the development of the submandibular gland. In addition, a conspicuous sexual dimorphism became increasingly apparent in the 6-, 7-, 10-, and 12-week-old animals, due to the remarkable development of the granular convoluted tubules in the adult male mouse, that expressed abundant NGF mRNA.
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