AI Article Synopsis
- Phytoestrogens are compounds that share structural similarities with estrogen and have weak estrogen-like activity, prompting interest in their potential health benefits.
- Recent studies suggest that consuming phytoestrogens may lower cancer mortality rates, fueling research into their therapeutic roles in oncology.
- This review focuses on new insights into how phytoestrogens might affect mitochondrial functions in breast cancer, indicating a need for further research to clarify their specific impacts and potential as cancer treatments.
Article Abstract
Phytoestrogens were originally identified as compounds having a close similarity in structure to estrogens and harboring weak estrogen activity. The interest in phytoestrogens as potential therapeutic agents has recently risen in the field of oncology, since population based studies have linked phytoestrogens consumption with a decreased risk of mortality due to several types of cancer. This review departs from the main focus of these articles by describing recent advances in our understanding of phytoestrogen potential action on mitochondria, specifically on mitochondrial biogenesis, dynamics and functionality, as well as mitoptosis in breast cancer. Further studies are necessary to explain the effects of individual phytoestrogens on mitochondrial biogenesis and dynamics and for designing of new therapy targets for cancer treatment, nevertheless area promising therapeutic approach.
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| http://dx.doi.org/10.2174/1381612820666140306100709 | DOI Listing |
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