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Osimertinib-Induced Toxic Epidermal Necrolysis - A Case Report.
Pril (Makedon Akad Nauk Umet Odd Med Nauki)
November 2024
Faculty of Medicine, University Clinic of Radiotherapy and Oncology, Skopje, Macedonia.
Purpose: To investigate the rare side effects of Osimertinib in a case of toxic epidermal necrosis.
Case Presentation: We report on a case of a 44-year old woman with lung adenocarcinoma harboring an EGFR-sensitizing mutation who was treated with Osimertinib as the second-line treatment. Ten days after Osimertinib initiation, a diffuse erythematous rash rapidly spread over the patient's trunk along with vesicles and purpuric macules; furthermore, she developed erythema and exfoliation on the face and trunk and severe mucositis.
Rash Evaluation in a Transplant Patient.
Ann Clin Lab Sci
September 2024
Department of Pediatrics, Division of Infectious Diseases, State University of New York Health Sciences University, Brooklyn, NY, USA.
Article Synopsis
- A 62-year-old male lung transplant recipient developed a sudden rash two months after starting new medications, raising concerns about a potential drug allergy.
- Skin biopsy results indicated a drug reaction, but the patient's treatment with high-dose prednisone complicated allergy testing.
- The case highlights the challenges in diagnosing drug allergies in transplant patients, emphasizing the need for better diagnostic strategies to avoid misdiagnosis and improve care.
Normocomplementemic Urticarial Vasculitis Following Influenza Vaccination: A Case Report and Review of the Literature.
Int Med Case Rep J
September 2024
Department of Dermatology, International University of Health and Welfare, Narita Hospital, Chiba, Japan.
Article Synopsis
- Urticarial vasculitis is a condition marked by long-lasting hives and can be triggered by medications, infections, autoimmune disorders, or, as noted, certain vaccinations.
- The case study discusses a 67-year-old woman who developed a rash three days post-influenza vaccination, leading to a diagnosis of normocomplementemic urticarial vasculitis, which resolved after treatment.
- The review highlights that while vaccine-associated vasculitis is common, urticarial vasculitis after vaccination is rare, and the underlying mechanisms are not well understood, suggesting a need for further research.
Erythema multiforme-like papules after COVID vaccine administration.
Dermatol Online J
June 2024
Garden City Dermatology, Garden City, New York, USA.
A unique dermatopathology incident arose after administration of the mRNA-1273 SARS-CoV-2 (Moderna) vaccine. Specifically, a transient purpuric interface dermatitis occurred 5 days post-second vaccine with the presentation of erythematous papules with erythema multiforme-type findings. A patient developed purpuric interface dermatitis with micro-vesiculation post-vaccination which ultimately resolved without sequelae.
View Article and Find Full Text PDFArticle Synopsis
- Pyoderma gangrenosum is a rare skin disease that causes painful ulcers with specific characteristics and can occur alongside other conditions like rheumatoid arthritis and inflammatory bowel disease.
- A unique case was reported involving a 67-year-old obese female who had both pyoderma gangrenosum and IgA vasculitis, leading to large, rapidly expanding skin wounds.
- Treatment with a TNF-α inhibitor (adalimumab) successfully reduced the ulceration and promoted healing after initial treatment with oral prednisolone.
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