The synthesis of (diarylmethyl)sulfonamides and related compounds by a new manganese-mediated, cobalt-catalyzed three-component reaction between sulfonamides, carbonyl compounds and organic bromides is described. This organometallic Mannich-like process allows the formation of the coupling products within minutes at room temperature. A possible mechanism, emphasizing the crucial role of manganese is proposed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944212 | PMC |
| http://dx.doi.org/10.3762/bjoc.10.39 | DOI Listing |
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