Background: Fibro-osseous lesion is a broad term for a diverse group of jaw disorders characterized by the replacement of normal bone by a benign fibrous connective tissue matrix. The present study reviewed the clinico-pathologic characteristics of all biopsied cases of fibro-osseous lesions at our hospital from 1990 to 2011, which we hope will serve as a reference database regionally.
Methods: A retrospective clinicopathological review of all histologically diagnosed cases of jaw fibro-osseous lesions seen at our Hospital between January 1990 and December 2011.
Results: A total of one hundred and twenty one fibro-osseous lesions of jaws were histological diagnosed in the 22-year period. The lesions documented included ossifying fibroma (62%), fibrous dysplasia (37.2%) and florid cemento-osseous dysplasia (0.8%). Fibro-osseous lesions of jaws were more in females (61.2%) than males (38.8%), giving a male to female ratio of 1:1.6.
Conclusion: Fibro-osseous lesions of jaw are a diverse group and since it may not be possible to adequately separate them histologically, the development of a more rigorous clinical algorithm as indicated in this study is essential in reaching a final diagnosis especially in resource-limited settings.
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J Clin Endocrinol Metab
January 2025
Metabolic Diseases Branch, Bldg. 10/Rm 8C-101, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
Establishing genotype-phenotype correlations in disorders of hereditary endocrine neoplasia is important for clinical screening, genetic counseling, prognostication, surveillance, and surgical strategy, and may also provide clues about disease pathogenesis. Important genotype-phenotype correlations are recognized, for example, in pheochromocytoma/paraganglioma and multiple endocrine neoplasia type 2A. The presence of such correlations has been less clear in other familial endocrine disorders associated with primary hyperparathyroidism including multiple endocrine neoplasia type 1 (MEN1), and the hyperparathyroidism-jaw tumor syndrome (HPT-JT).
View Article and Find Full Text PDFBrain Sci
November 2024
Department of Neurological Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Background: Fibrous dysplasia (FD) is often difficult for skull base surgeons to address. FD arises due to the abnormal proliferation of fibroblasts, ultimately resulting in immature osseous tissue replacing normal cancellous bone. When the skull base is involved, it can result in cranial nerve compression.
View Article and Find Full Text PDFCureus
December 2024
Department of Reconstructive and Maxillofacial Surgery, Hassan II University Hospital of Fez, Fez, MAR.
Florid osseous dysplasia (FOD) is a rare, benign fibro-osseous lesion primarily involving the mandible and maxilla, with a higher prevalence in middle-aged women of African or Asian descent. This article presents a case of mandibular FOD complicated by secondary infection, emphasizing clinical presentation, diagnostic challenges, and treatment strategies. The unique radiographic features of FOD necessitate careful differential diagnosis to prevent misdiagnosis with other jaw lesions.
View Article and Find Full Text PDFOral Dis
December 2024
Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Objective: To assess the sclerostin, β-catenin, and tryptase expression in fibro-osseous lesions (FOL) of the jaws.
Subjects And Methods: Immunohistochemistry analysis was performed for these proteins on FOL and non-lesional bone. The sclerostin-positive cells were scored from 0 (no expression) to 3 (high expression).
Curr Opin Otolaryngol Head Neck Surg
February 2025
Department of Otolaryngology - Head & Neck Surgery, University of Florida, Gainesville, Florida, USA.
Purpose Of Review: Fibro-osseous lesions (FOL) are benign, slow-growing lesions that are often incidentally discovered in the sinonasal cavity. They may necessitate surgical resection in patients with postobstructive sinusitis, or in cases of cranial nerve and orbital compression. We examine the recent advancements in otolaryngology relating to diagnostic characteristics and treatments for FOL, with emphasis on new technologies to improve outcomes and reduce recurrence.
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