Manganese-deficient rats exhibited seven-fold lower preproinsulin mRNA levels compared to control, as detected by dot blot hybridization of both total and poly(A)+ RNA using a preproinsulin cDNA probe. No differences in the size of the insulin mRNA were observed. Thus, decreased mRNA levels may be a major contributing factor to the decreased insulinogenesis observed in manganese-deficient rats.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0014-5793(88)80544-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Functional disorder of the retina in manganese-deficient Japanese quail revealed by electroretinography using a contact lens electrode with built-in light source.
J Vet Med Sci
February 2008
Department of Toxicology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
Manganese deficiency results in neurological and skeletal defects, together with ultrastructural disarrangement of the retina in rats. Wild birds show a range of Mn concentrations in their tissues, including the liver, raising the possibility of Mn-related disorders in the wild. Electroretinography (ERG) provides a useful noninvasive approach to evaluate visual function.
View Article and Find Full Text PDFCyclo-oxygenase inhibition restores the attenuated vasodilation in manganese-deficient rat aorta.
J Nutr
September 2006
Department Physiology and Biophysics, School of Medicine, University of Louisville, KY 40292, USA.
Previously we showed that manganese (Mn) deficiency enhances the arterial contractile response to alpha(1) adrenergic stimuli and affects vasomotor tone. The aim of this study was to test the hypothesis that dietary Mn deficiency inhibits the vasodilation pathways of rat aorta. Vascular ring studies were conducted in aortic rings from weanling male Sprague-Dawley rats that were fed either a Mn deficient (MnD) or a Mn adequate/control diet (MnA) (<1 and 12 mg/kg Mn, respectively) for a 14-wk period.
View Article and Find Full Text PDFBrain manganese concentrations in rats following manganese tetroxide inhalation are unaffected by dietary manganese intake.
Neurotoxicology
July 2002
CIIT Centers for Health Research, Research Triangle Park, NC 27709-2137, USA.
Manganese-deficient individuals have decreased manganese elimination. This observation has prompted suggestions that relative manganese deficiency may increase the risk for manganese neurotoxicity following inhalation exposure. The objective of this study was to determine whether dietary manganese intake influences the pharmacokinetics of inhaled manganese tetroxide (Mn3O4).
View Article and Find Full Text PDFInfluence of dietary manganese on the pharmacokinetics of inhaled manganese sulfate in male CD rats.
Toxicol Sci
April 2001
CIIT Centers for Health Research, 6 Davis Drive, P.O. Box 12137, Research Triangle Park, North Carolina 27709-2137, USA.
Concerns exist as to whether individuals with relative manganese deficiency or excess may be at increased risk for manganese toxicity following inhalation exposure. The objective of this study was to determine whether manganese body burden influences the pharmacokinetics of inhaled manganese sulfate (MnSO(4)). Postnatal day (PND) 10 rats were placed on either a low (2 ppm), sufficient (10 ppm), or high (100 ppm) manganese diet.
View Article and Find Full Text PDFCorneal changes in manganese-deficient rats.
Cornea
July 1999
Department of Ophthalmology, Nagasaki University School of Medicine, Japan.
Purpose: This study was undertaken to examine the changes in the cornea due to dietary manganese (Mn) deficiency in Wistar-Kyoto rats, because there is a lack of information on the significance of manganese in the cornea.
Methods: Mature female Wistar-Kyoto albino rats were mated with males. All pregnant females were divided into Mn-deficient and control groups.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!