The spontaneous hepatomas of male mice (CBA X C57B1/6)F1 were studied using complex cytologic, histologic, immunochemical, and cytochemical methods. The AFP was detected in trace amount in the serum of tumour-bearing mice and in single cells of hepatomas. As a rule the hepatocarcinoma cells have the polymodal DNA distribution (2C-8C) with major peak of 4 C (in 18 out of 26 cases). More rarely the tumours with predominant diploid and octoploid cells were observed.
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