A scalable de novo synthesis of difluoromethyl pyridines from inexpensive materials is reported. The pyridyl subunit is built around the difluoromethyl group rather than a late stage introduction of this moiety. This user-friendly approach allows access to a diverse range of substitution patterns on all positions on the ring system and on the difluoromethyl group.
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Article Synopsis
- - The study focuses on the synthesis of perfluoro-butyl secondary amines, which have various potential applications but are challenging to produce.
- - The authors introduce an efficient method for synthesizing these amines directly from readily available trifluoromethyl secondary amines, involving three key chemical reactions.
- - This new approach utilizes only one trifluoromethyl source, effectively eliminates hydrogen fluoride, and is compatible with different functional groups, making it a promising technique, especially for medical imaging applications.
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