Objective: Cholesterol granulomas are benign lesions that sometimes occur on the petrous apex (PA). We report our experience using an endoscopic endonasal approach to remove PA cholesterol granulomas.
Material And Methods: A retrospective patient chart analysis was conducted at a tertiary care university hospital.
Results: Four patients (3 females, 1 male) were included in this study. Patients' ages ranged from 27 to 78 years. Computed tomography (CT) and magnetic resonance imaging (MRI) for diagnosis and computer-assisted navigation were performed. The most common symptom was abducens nerve palsy. The largest granuloma measured 5 x 2 cm and was located on the left side. An endoscopic endonasal approach was chosen and navigation was applied (3/4 patients) to identify the optimal area for opening the granuloma. No complications occurred, and patients were free from recurrence during the follow-up period.
Conclusion: The endoscopic endonasal approach to PA cholesterol granulomas is feasible and safe. Intra-operative navigation is recommended to identify the position of the internal carotid artery and determine the safest area for opening the granuloma without damaging the artery. Another advantage of this approach is an easier follow-up through diagnostic nasal endoscopy.
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Zhonghua Yi Xue Za Zhi
December 2024
Otology Medical Center, the First People's Hospital of Foshan, Hearing and Balance Medical Engineering Technology Research and Development Center of Guangdong Province, Foshan528000, China.
This study aimed to investigate the surgical efficacy of middle ear cholesterol granuloma using otoendoscopy. A total of 23 patients (9 males and 14 females) aged (38±18) years who were diagnosed with middle ear cholesterol granuloma at the Otology Medical Center, the First People's Hospital of Foshan from May 2020 to August 2023 were retrospectively analyzed. Based on clinical characteristics of the lesions, the patients were categorized into retention type and granulation type; the latter was further subdivided into localized and extensive types.
View Article and Find Full Text PDFNeurocirugia (Astur : Engl Ed)
January 2025
Departamento de Radiología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Petroclival lesions represent a surgical challenge during the endonasal endoscopic approach, as they may involve maneuvers with severe comorbidity. To avoid the morbidity caused by these maneuvers, a contralateral transmaxillary approach (CTA) has been proposed to complement the endoscopic endonasal approach. The aim of our study is to review the safety and efficacy of this approach.
View Article and Find Full Text PDFInfect Immun
December 2024
Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
To control schistosomiasis mansoni, it is important to attempt preventing the worms' egg-induced pathology in the liver and limiting pathogen transmission following egg exit from the intestines to the exterior. Therefore, the present study aimed to clarify the reasons behind the decades-long riddle of periovular granulomas downmodulation in the liver, but not the small intestine, with the progression of murine schistosomiasis mansoni. Outbred female CD-1 mice were percutaneously exposed to 15 cercariae.
View Article and Find Full Text PDFGen Thorac Cardiovasc Surg Cases
August 2024
Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Background: Cholesterol granuloma (CG) is a benign entity characterized by the presence of cholesterol crystals and foreign body giant cells. This condition can be attributed to cholesterol crystals that are deposited in the tissues and react with foreign body giant cells, resulting in granuloma formation. Lesions commonly develop in the otolaryngeal region, such as the middle ear.
View Article and Find Full Text PDFCureus
October 2024
Anesthesia and Critical Care, King Abdulaziz University Faculty of Medicine, Jeddah, SAU.
Intraoperative patient movement under general anesthesia, even with multiple monitoring modalities and adequate anesthetic depth, is rare but can lead to serious complications. Such movements are particularly dangerous in neurosurgical procedures, where precision is crucial. Similar risks exist in ophthalmic, spinal, and cardiac surgeries, where patient immobilization is vital to prevent adverse outcomes.
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