Background: In a phase III trial, older patients with acute myeloid leukemia (N=485) received decitabine or treatment choice (supportive care or cytarabine). This post hoc analysis examined whether baseline renal and hepatic function and white blood cell (WBC) counts predicted response.
Methods: Baseline WBCs and renal and liver function markers were tabulated for responders/nonresponders.
Results: Nonresponders had higher mean baseline creatinine (P=0.005). Creatinine data showed no significant between-group differences by treatment within responder category.
Conclusions: No relationship was found between baseline WBCs or hepatic function and response. Higher baseline creatinine in nonresponders may not be clinically relevant.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939385 | PMC |
| http://dx.doi.org/10.1016/j.lrr.2013.12.001 | DOI Listing |
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