AI Article Synopsis
- HERV-H is associated with leukaemias and lymphomas, and this study aims to investigate its prevalence and impact in Singapore's diverse population.
- The research found that Malays and Indians are significantly more likely to be HERV-H positive compared to Chinese individuals, with higher odds for both groups.
- Additionally, there is a strong positive correlation between HERV-H positivity and the incidence rates of Hodgkin's lymphoma among the three ethnic groups, indicating a potential link between genetic predisposition and cancer risk.
Article Abstract
Human endogenous retrovirus-H (HERV-H) is implicated in leukaemias and lymphomas, but the precise molecular mechanism underlying HERV-mediated carcinogenesis remains unknown. We determined the prevalence of HERV-H in a cross-section of the Singapore population and explored the relationship between HERV-H positivity and incidence rates for Hodgkin's lymphoma in three major ethnic groups of Singapore. We observed that Malays were 1.11 times likely (95% CI=1.05-1.17; P<0.01), and Indians 1.12 times likely (95% CI=1.07-1.18; P<0.01) to be HERV-H positive when compared to Chinese. Interestingly, the incidence rates of Hodgkin's lymphoma for the three races positively correlated to the respective prevalence rate for HERV-H positivity (r=0.9921 for male; r=0.9801 for female), suggesting that viral inheritance in human may predispose certain racial origin unfavourably to malignancy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939381 | PMC |
| http://dx.doi.org/10.1016/j.lrr.2013.10.001 | DOI Listing |
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