Background: Alzheimer's disease (AD) is one of the most common degenerative neurological disorders among elderly people, and is associated with progressive cerebral atrophy. AD is characterized by deterioration of the memory, difficulties with language, alterations in behavior and dysfunction in daily activities.
Objectives: The purpose of the present study was to measure the total volumes of different parts of the brain of AD patients and healthy gender-matched controls using Cavalieri's volume estimate method, and to establish some brain ratios. Moreover, the authors wanted to test this method in measuring the volumes of various parts of the brain from MRI scans.
Material And Methods: In this study, the MRI scans of 15 right-handed individuals with probable AD and 10 healthy controls were assessed. Cavalieri's volume estimate method was applied to the brain MRI scans to calculate the volumes of various parts of the brain.
Results: While the measurements showed a marked increase in the volume of cerebral ventricles and sulci in AD patients in comparison to the gender-matched controls, the volumes of cortical gray matter and cerebral hemispheric brain matter were reduced considerably. However, no significant differences were detected in the volume of the cerebellum + brainstem or intracranium in AD patients. There were also no major variations between male and female values of the two groups.
Conclusions: Overall, cerebral hemisphere and cortical gray matter atrophies were the most remarkable findings among AD patients in the present study; consequently, expansions of both the ventricles and subarachnoid space were formed. Cavalieri's volume estimate method was very efficient in calculating the volumes of different parts of brain from the MRI scans of both groups.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Background: Connected speech has been explored as a possible marker for Alzheimer's disease (AD) by employing language models based on machine learning. However, most previous approaches are based on scene description tasks, and it is unclear how different types of connected speech and differences across subjects' speech relate to changes in their brains.
Method: We analyzed transcripts of Flemish Dutch connected speech from interviews from 74 cognitively healthy elderly adults (mean MMSE = 28.
A copula-based multivariate flood frequency analysis under climate change effects.
Sci Rep
January 2025
Department of Civil Engineering, Isfahan University of Technology, Isfahan, Iran.
Floods are among the most severe natural hazards, causing substantial damage and affecting millions of lives. These events are inherently multi-dimensional, requiring analysis across multiple factors. Traditional research often uses a bivariate framework relying on historical data, but climate change is expected to influence flood frequency analysis and flood system design in the future.
View Article and Find Full Text PDFConditions for shale gas accumulation and the gas-bearing factors of the Wufeng-Longmaxi formation in the Laifeng-Xianfeng area.
Sci Rep
January 2025
School of New Energy, Longdong University, Qingyang, 745000, China.
In this work, taking wells LD1, LD2, and LY2 in the Laifeng-Xianfeng area as the research target, through core description, intensive core sampling, experimental analysis, imaging logging and other methods, the characteristics of graptolite zone development, organic carbon content, mineral composition, shale reservoir properties and the gas-bearing properties of the Wufeng-Longmaxi Formation shale are systematically analyzed. The main factors affecting the gas-bearing capacity of the Wufeng-Longmaxi Formation shale are extensively evaluated. The results reveal the following: ① The Wufeng-Longmaxi Formation shale, which was deposited in a deep-water shelf environment, has a large thickness (50-60 m) and a stable distribution.
View Article and Find Full Text PDFReal-life dosing conditions in older adults and geriatric patients in Poland - an international questionnaire study to investigate the regional differences in drug intake behaviour in the older population.
Eur J Pharm Sci
December 2024
Center of Drug Absorption and Transport, Department of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmacy, University of Greifswald, Felix-Hausdorff-Str. 3, 17489 Greifswald, Germany.
Older people represent approximately 20% of the Polish population and are the primary population using medications. Behaviours connected with drug intake (such as dosage form modifications, type and amount of fluid and/or food accompanying administration) are crucial for drug efficacy and avoidance of adverse effects. The presented study had three research aims; firstly, to investigate the real-life drug administration process among older adults and geriatric patients in Poland.
View Article and Find Full Text PDFEstablishment of Select Printing Parameters for Low-Cost Fused Deposition Modeling Printed Cast Iron Through Experimental Optimization.
3D Print Addit Manuf
October 2024
School of Engineering, University of Guelph, Guelph, Ontario, Canada.
The fused deposition modeling (FDM) form of additive manufacturing provides a low-cost opportunity to quickly create unique parts with complex geometries using a high degree of precision. This is accomplished through a layer-by-layer extrusion of a metallic infused thermoplastic from a heated nozzle onto a build plate, until the 3D part is achieved. The ability to produce cheaply manufactured FDM printed cast iron parts would allow industries to bypass casting lead times and create custom cast iron parts without a machined mold.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!