The study describes the synthesis of new geminally disubstituted C-linked carbo-β(2,2)-amino acids (β(2,2)-Caas) with different carbohydrate side chains, and their use in the synthesis of β(2,2)-peptides. The study infers that the side chain has an influence on the synthesis of peptides and their conformational behaviour.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.carres.2014.01.026 | DOI Listing |
Health Econ
January 2025
Department of Agricultural and Applied Economics, University of Georgia, Athens, Georgia, USA.
Urban environments are thought to improve food security, by offering enhanced access to markets and income opportunities. Yet this idea is hard to test empirically due to an abundance of confounding factors and selection issues. This study leverages a resettlement program in China to provide the first quasi-experimental estimate of city life on food consumption and nutrition among low-income households.
View Article and Find Full Text PDFBiotechnol Adv
January 2025
TEDA Institute of Biological Sciences and Biotechnology, Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin, PR China; Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin, PR China; Nankai International Advanced Research Institute, Nankai University, Shenzhen, China. Electronic address:
Protein glycosylation, which involves the addition of carbohydrate chains to amino acid side chains, imparts essential properties to proteins, offering immense potential in synthetic biology applications. Despite its importance, natural glycosylation pathways present several limitations, highlighting the need for new tools to better understand glycan structures, recognition, metabolism, and biosynthesis, and to facilitate the production of biologically relevant glycoproteins. The field of bacterial glycoengineering has gained significant attention due to the ongoing discovery and study of bacterial glycosylation systems.
View Article and Find Full Text PDFPLoS Negl Trop Dis
January 2025
Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.
Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, continues to pose global health challenges. Current treatments face issues like resistance, safety, efficacy, and cost. This review covers the discovery, mechanisms of action, clinical applications, and limitations of key antileishmanial agents: pentavalent antimonials, amphotericin B, miltefosine, paromomycin, and pentamidine.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Botany, M.D. Science College, Porbandar, Gujarat, 360575, India.
Since the emergence of the coronavirus disease, there has been a notable surge in demand for herbal remedies with minimal or no adverse effects. Notably, existing vaccines and medications employed in its treatment have exhibited significant side effects, some of which have proven fatal. Consequently, there is an increasing focus on pharmacological research aimed at identifying optimal solutions to this challenge.
View Article and Find Full Text PDFSci Rep
January 2025
Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu , Tokyo, 183-8509, Japan.
Organoids are stem cell-derived three-dimensional tissue cultures composed of multiple cell types that recapitulate the morphology and functions of their in vivo counterparts. Organ-on-a-chip devices are tiny chips with interconnected wells and channels designed using a perfusion system and microfluidics to precisely mimic the in vivo physiology and mechanical forces experienced by cells in the body. These techniques have recently been used to reproduce the structure and function of organs in vitro and are expected to be promising alternatives for animal experiments in the future.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!