The paper reviews the results of development of steady-state arc-discharge plasma generator with directly heated LaB6 cathode. This arc-discharge plasma generator produces a plasma jet which is to be converted into an atomic one after recombination on a metallic plate. The plate is electrically biased relative to the plasma in order to control the atom energies. Such an intensive jet of hydrogen atoms can be used in negative ion sources for effective production of negative ions on a cesiated surface of plasma grid. All elements of the plasma generator have an augmented water cooling to operate in long pulse mode or in steady state. The thermo-mechanical stresses and deformations of the most critical elements of the plasma generator were determined by simulations. Magnetic field inside the discharge chamber was optimized to reduce the local power loads. The first tests of the steady-state arc plasma generator prototype have performed in long-pulse mode.
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http://dx.doi.org/10.1063/1.4835415 | DOI Listing |
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Dermatology, Dongshan Hospital, Guofengyuan Building, Xuezi Avenue, Meijiang District, Meizhou, 514011, Guangdong, China.
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View Article and Find Full Text PDFAnal Chem
January 2025
Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
Developing ambient ionization methods for direct mass spectrometry (MS) analysis is crucial for achieving sample-to-answer capabilities, especially for rapid analysis and monitoring in specific scenarios. Herein, a compact device is presented that utilizes mesh-collision microtube plasma (MC-μTP) ionization for direct online MS analysis. This device features a self-aspirating design that enables the direct analysis of various sample types.
View Article and Find Full Text PDFRev Sci Instrum
January 2025
College of Advanced Interdisciplinary Studies, National University of Defense Technology, Changsha 410072, China.
High power pulse generators are moving in the direction of compact, solid-state, and stable working in a relatively long time. In this paper, a compact pulse forming line-Marx type high power pulse generator, based on a ceramic pulse forming line and a spark gap switch with carbide modified graphite electrodes, is studied numerically and experimentally. Specifically, a ceramic based pulse forming line with high relative permittivity was used to achieve long pulse duration in a limited dimension.
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J Med Chem
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Synthetic lethality offers a robust strategy for discovering the next generation of precision medicine therapies tailored for molecularly defined patient populations. MAT2A inhibition is synthetically lethal in several cancers that exhibit a homozygous deletion of -methyl-5'-thioadenosine phosphorylase (MTAP). Herein, we report the identification of novel MAT2A inhibitors featuring a spiral ring to circumvent the C-N atropisomeric chirality utilizing structure-based drug design.
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