AI Article Synopsis
- - Three new norditerpenoid alkaloids (nigelladines A-C) and one pyrroloquinoline alkaloid (nigellaquinomine) were extracted from the plant Nigella glandulifera, each with unique chemical structures featuring highly conjugated systems.
- - The specific 8aS-configuration of nigelladines A and B was confirmed through experimental comparisons with calculated electronic circular dichroism spectra.
- - These isolated alkaloids demonstrated significant inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) but showed no cytotoxic effects on the A431 cell line even at a concentration of 100 μM.
Article Abstract
Three norditerpenoid alkaloids, nigelladines A-C (1-3), and one pyrroloquinoline alkaloid, nigellaquinomine (4), all possessing new skeletons with highly conjugated systems, were isolated from Nigella glandulifera. The 8aS-configuration for 1 and 2 was determined by comparison of the experimental and calculated electronic circular dichroism spectra. These alkaloids exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity but are devoid of cytotoxicity against the A431 cell line at 100 μM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/np4009078 | DOI Listing |
Publication Analysis
Top Keywords
highly conjugated
8
ptp1b inhibitory
8
inhibitory activity
8
nigella glandulifera
8
conjugated norditerpenoid
4
norditerpenoid pyrroloquinoline
4
pyrroloquinoline alkaloids
4
alkaloids potent
4
potent ptp1b
4
activity nigella
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!