Objective: To evaluate the effect of a copper intrauterine device on the expression of mucin- 1 (MUC1) and İntegrin β1 in the luteal phase endometrium.
Material And Methods: 25 regularly menstruating women (25-35 years) who were willing to use copper intrauterine device contraception participated in this study. Endometrial sampling via a Pipelle canulla was performed on the 24(th) day of their cycle and repeated three months after insertion of TCu380A IUD. Immunohistochemical staining was performed for MUC1 and integrin β1 in the endometrial sections. Staining intensity was graded under the conventional light microscope.
Results: The mean age of the study population was 32.8±5.3 years (25-35). MUC1 expression of the endometrial luminal epithelium cytoplasm and the luminal epithelium increased significantly after three months of IUD usage (p=0.01; p<0.001 respectively). Neither integrin β1 expression of endometrial luminal epithelium cytoplasma nor of the endometrial stroma changed after three months of IUD usage (p=0.16; p=0.22 respectively).
Conclusion: The increase of the embryo implantation inhibitor MUC1 synthesis may be responsible for the IUD's mechanism of action for pregnancy prevention. Integrin β1 expression of the endometrial luminal epithelium cytoplasm and stroma are not affected by the use of copper IUD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939164 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Copper homeostasis and pregnancy complications: a comprehensive review.
J Assist Reprod Genet
January 2025
Department of Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Pregnancy complications pose challenges for both pregnant women and obstetricians globally, with the pathogenesis of many remaining poorly understood. Recently coined as a mode of cell death, cuproptosis has been proposed but remains largely unexplored. This process involves copper overload, resulting in the accumulation of fatty acylated proteins and subsequent loss of iron-sulfur cluster proteins.
View Article and Find Full Text PDFMigrated intra-uterine device to infra-umbilical skin: a rare case report.
BMC Womens Health
December 2024
Department of Obstetrics and Gynecology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Introduction: IUDs are effective, reversible and safe methods of contraception. The mechanism of action of IUDs as a group is inducing endometrial atrophy, apoptosis, altering tubal motility; preventing sperm permeability, fertilization, and implantation. Complications of IUD include menstrual disturbance, pelvic pain, and increased risk of ectopic pregnancy with contraceptive failure, device expulsion, uterine perforation or transmural migration with misplacement of the device.
View Article and Find Full Text PDFComparison of levonorgestrel in different forms and copper intrauterine devices for emergency contraception: A systematic review and meta-analysis.
Eur J Obstet Gynecol Reprod Biol
December 2024
Faculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.
Objective: Emergency contraception serves as the only dependable method for women to prevent pregnancy following unprotected sex. Among emergency contraception methods, the copper intrauterine device provides continuous, highly effective contraception for over a decade. This study aimed to evaluate the effectiveness, safety, and side effects of the copper intrauterine device over methods containing levonorgestrel for emergency contraception.
View Article and Find Full Text PDFFragmentation of an In-Date Copper Intrauterine Device: An Unusual Complication.
Cureus
November 2024
Obstetrics and Gynaecology, East Suffolk and North Essex NHS Foundation Trust, Colchester, GBR.
We present a rare case involving a 25-year-old woman who had fragmentation of a copper intrauterine contraceptive device (IUD) while still within its recommended lifespan. The patient's symptoms included lower abdominal pain, offensive vaginal discharge, and the passage of copper IUD fragments. The pelvic examination confirmed the presence of the copper IUD strings, and with her consent, the device was removed.
View Article and Find Full Text PDFTips and tricks for the management of contraceptive etonogestrel implant in clinical practice: an Expert Opinion.
Eur J Contracept Reprod Health Care
December 2024
Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
Article Synopsis
- The global use of long-acting reversible contraceptives (LARCs) is rising because they more effectively prevent unintended pregnancies compared to short-acting methods, especially in teens.
- LARCs include options like intrauterine devices and subcutaneous implants, with specialized training required for their application.
- This Expert Opinion focuses on the etonogestrel (ENG)-releasing implant, offering updated guidance on insertion, removal, and managing unscheduled bleeding based on extensive clinical experience.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!