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Transforming Medicine: Advances in Gene Therapy, Immunotherapy, and Targeted Cures.
Curr Protein Pept Sci
January 2025
Galgotias College of Pharmacy, Pharmacy, Greater Noida, Uttar Pradesh, 201310, India.
In recent years, novel therapeutic approaches have revolutionized the landscape of medicine, offering promising avenues for the cure of various diseases. The novel approaches explore advancements in gene therapy in pharmaceuticals, immunotherapy, RNA-based therapeutics, cell-based therapies, and targeted tumor therapies. Gene therapy has emerged as a groundbreaking approach, leveraging genetic material to cure or prevent diseases by targeting defective genes.
View Article and Find Full Text PDFAddressing residual and recurrent aneurysms post-Woven EndoBridge device embolization: a systematic review and meta-analysis.
J Neurointerv Surg
January 2025
Department of Neurosurgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA
Background: Early literature on the Woven EndoBridge (WEB) device reported 80-90% adequate aneurysm occlusion but low complete occlusion (40-55%). It is uncertain whether residual or recurrent aneurysms require re-treatment to prevent future rupture.
Objective: To systematically review the literature to meta-analyze occlusion and complication rates after re-treatment of these aneurysms.
Comparative Efficacy of Nonsteroid Immunosuppressive Medications in Childhood Nephrotic Syndrome.
JAMA Pediatr
January 2025
Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Importance: Cyclophosphamide and calcineurin inhibitors are the most used nonsteroid immunosuppressive medications globally for children with various chronic inflammatory conditions. Their comparative effectiveness remains uncertain, leading to worldwide practice variation. Nephrotic syndrome is the most common kidney disease managed by pediatricians globally and suboptimal treatment is associated with high morbidity.
View Article and Find Full Text PDFLingual Arch-supported Open Coil Space Regainer.
Int J Clin Pediatr Dent
December 2024
Department of Orthodontics and Dentofacial Orthopedics, JMF's ACPM Dental College, Dhule, Maharashtra, India.
Aim And Background: The lingual arch has been widely used as a space maintainer in the lower arch during the mixed dentition phase, and the open-coil space regainer (OCSR) has been used for localized space regaining. However, an appliance consisting of both has not been previously documented. This case report highlights the advantages of using a lingual-arch-supported OCSR for regaining lost space.
View Article and Find Full Text PDFEffectiveness of a timed praziquantel treatment of school children in relation to seasonal transmission of urogenital schistosomiasis in Northwestern Tanzania.
Acta Trop
January 2025
Klinikum Wuerzburg Mitte GmbH, Medical Mission Hospital, Department of Tropical Medicine, Würzburg, Germany.
Background: Regular mass drug administration of praziquantel has a positive impact on reducing the burden of human schistosomiasis, however transmission still persists in many areas. To reach disease elimination; tailored interventions are needed to not only further reduce infections but also to tackle areas of persistent high prevalences of infection. One proposed approach is timed treatment based on the natural disease transmission cycle in relation to seasons.
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