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RhD-Alloimmunization in Adult and Pediatric Trauma Patients.
Transfus Med Rev
October 2024
Standards Development and Quality Initiatives, Association for the Advancement of Blood and Biotherapies, Bethesda, MD, USA.
The actual risk of providing RhD-positive units to RhD-negative recipients remains debatable. There is no standard of care in the United States (US) to guide transfusion decisions regarding RhD type for patients with an unknown blood type, except for women of childbearing age and neonates. The risk of alloantibody formation by an RhD-negative patient exposed to RhD-positive blood is reported to be from 3% to 70%.
View Article and Find Full Text PDFNon-Invasive Prenatal Fetal Blood Group Genotype and Its Application in the Management of Hemolytic Disease of Fetus and Newborn: Systematic Review and Meta-Analysis.
Transfus Med Rev
April 2021
Thrombosis and Vascular Diseases Laboratory, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia. Electronic address:
Hemolytic disease of fetus and newborn (HDFN) imposes great healthcare burden being associated with maternal alloimmunization against parental-inherited fetal red blood cell antigens causing fetal anemia or death. Noninvasive prenatal analysis (NIPT) provides safe fetal RHD genotyping for early identification of risk pregnancies and proper management guidance. We aimed to conduct systematic review and meta-analysis on NIPT's beneficial application, in conjunction with quantitative maternal alloantibody analysis, for early diagnosis of pregnancies at risk.
View Article and Find Full Text PDFApproach to red blood cell antibody testing during pregnancy: Answers to commonly asked questions.
Can Fam Physician
July 2020
Transfusion Medicine Specialist in the Department of Laboratory Medicine and Pathobiology at the University Health Network in Toronto, Assistant Professor in the Department of Laboratory Medicine and Pathobiology at the University of Toronto, a consultant in the neonatal intensive care unit and in the Department of Laboratory Medicine and Molecular Diagnostics at Sunnybrook Health Sciences Centre, and Program Investigator in the Quality in Utilization, Education, and Safety in Transfusion (QUEST) research collaboration at the University of Toronto.
Objective: To provide family physicians with an understanding of blood bank tests performed during pregnancy. The value of routine blood type and antibody tests, as well as the follow-up required when a patient develops a red blood cell antibody or experiences a fetal-maternal hemorrhage (FMH) will be reviewed.
Sources Of Information: The approach described is based on the authors' clinical expertise and peer-reviewed literature from 1967 to 2020.
Relevance and costs of RHD genotyping in women with a weak D phenotype.
Transfus Clin Biol
February 2019
Établissement français du sang Provence Alpes Côte d'Azur Corse, laboratoire d'immuno-hématologie, site Marseille, Marseille, France.
Objectives: For pregnant women, the serologic test results of D antigen will determine the frequency of RBC antibody detection as well as the indication for RhIG prophylaxis. RHD genotyping is the only method that may provide clear guidance on prophylaxis for women with a weak D phenotype. This analysis evaluated the economical implications of using RHD genotyping to guide RhIG prophylaxis among pregnant women with a serological weak D phenotype.
View Article and Find Full Text PDFA randomised controlled trial and economic evaluation of intraoperative cell salvage during caesarean section in women at risk of haemorrhage: the SALVO (cell SALVage in Obstetrics) trial.
Health Technol Assess
January 2018
Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Article Synopsis
- Caesarean sections can lead to a lot of blood loss and sometimes require women to receive blood from donors, which isn't always a great option.
- The study aimed to see if using a method called "cell salvage," which collects and returns the mother's own lost blood, could lower the need for donor blood and make things safer for mothers.
- Researchers looked at over 3,000 women in the UK, comparing those who used cell salvage during surgery with those who didn't to see which method was better for health and costs.
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