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| http://dx.doi.org/10.1111/cns.12240 | DOI Listing |
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Diosmin induces mitochondrial-mediated apoptosis and anti-inflammatory effects in Hep-2 cells: an integrated in vitro and in silico analysis.
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January 2025
Department of Plant Science, Madurai Kamaraj University, Madurai, 625021, Tamil Nadu, India.
The present study aims to explore the anticancer efficacy of Diosmin by inducing mitochondrial-mediated apoptosis in human epidermoid carcinoma cells (Hep-2). This is done by cell line assays and studying crucial inflammatory and apoptotic signaling molecules. The cytotoxicity property of Diosmin was evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.
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J Inflamm Res
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The First Department of Critical Care Medicine, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, People's Republic of China.
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View Article and Find Full Text PDFGdX inhibits the occurrence and progression of breast cancer by negatively modulating the activity of STAT3.
Cancer Biol Ther
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Department of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Aim: To elucidate the biological functionality and regulatory mechanisms of GdX in breast cancer (BC).
Methods: The examination of GdX expression in human BC tissues and cell lines was conducted through immunohistochemical (IHC) and Western blot. Cell proliferation capacity was assessed via the CCK-8 and colony formation assay, while cell migration was determined through the wound healing assay.
Investigation of Apoptotic and Anticancer Effects of 2-substituted Benzothiazoles in Breast Cancer Cell Lines: EGFR Modulation and Mechanistic Insights.
Anticancer Agents Med Chem
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Department of Medical Biochemistry, Medical Faculty, Inonu University, Malatya, Turkey.
Background And Objective: Benzothiazole derivatives, a class of heterocyclic compounds, exhibited diverse biological activities influenced by substituents in the thiazole ring. This study aimed to synthesize these compounds with two functional groups to investigate their potential as anticancer agents, particularly against breast cancer. While previous research demonstrated the efficacy of 2-substituted benzothiazoles against glioma and cervical and pancreatic cancer cells, there is a gap in studies targeting breast cancer.
View Article and Find Full Text PDFNovel hydrazide-hydrazone containing 1,2,4-triazole as potent inhibitors of antiapoptotic protein Bcl-xL: Synthesis, biological evaluation, and docking studies.
Arch Pharm (Weinheim)
December 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, İstanbul University, İstanbul, Turkey.
This study describes the synthesis and characterization of a series of novel hydrazide-hydrazone derivatives containing a 1,2,4-triazole ring. The compounds were characterized using various spectroscopic techniques, such as FT-IR, H-NMR, C-NMR, HRMS, and elemental analysis. The antiproliferative activity of the synthesized compounds was evaluated against a panel of human cancer cell lines (HCT-116, HepG-2, KLN205, LTPA, U138, and SW620) and healthy cell lines (HSkMC and iPSCs).
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