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Epithelial Barrier in the Nasal Mucosa, Related Risk Factors and Diseases.
Int Arch Allergy Immunol
June 2023
Department of Otorhinolaryngology, The Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
As the first line of defense against risk factors, the nasal epithelial barrier maintains homeostasis in nasal mucosa. The composition of the epithelial barrier contains physical, chemical, immune, and microbiological barriers. Together, these barriers form the nasal defense against irritations.
View Article and Find Full Text PDFIdentification of an adhesive interface for the non-clustered δ1 protocadherin-1 involved in respiratory diseases.
Commun Biol
April 2020
Department of Chemistry and Biochemistry, The Ohio State University, 484 W 12th Avenue, Columbus, OH 43210 USA.
Cadherins form a large family of calcium-dependent adhesive proteins involved in morphogenesis, cell differentiation, and neuronal connectivity. Non-clustered δ1 protocadherins form a cadherin subgroup of proteins with seven extracellular cadherin (EC) repeats and cytoplasmic domains distinct from those of classical cadherins. Non-clustered δ1 protocadherins mediate homophilic adhesion and have been implicated in various diseases including asthma, autism, and cancer.
View Article and Find Full Text PDFRole of PCDH 1 Gene in the Development of Childhood Asthma and Other Related Phenotypes: A Literature Review.
Cureus
September 2018
Pediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
The asthma gene PCDH 1, encoding protocadherin-1, is a cellular adhesion molecule which plays an important role in epithelial barrier formation and repair. PCDH 1 is a novel susceptible gene not only in childhood asthma but also in eczema and other atopic phenotypes. In this article, we reviewed relevant articles from PubMed, Google Scholar, Science Direct and included all available significant pieces of information about the PCDH 1 association with asthma and other atopic or non-atopic phenotypes.
View Article and Find Full Text PDFProtocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma.
PLoS One
June 2017
Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Background: The asthma gene PCDH1 encodes Protocadherin-1, a putative adhesion molecule of unknown function expressed in the airway epithelium. Here, we characterize the localization, differential expression, homotypic adhesion specificity and function of PCDH1 in airway epithelial cells in asthma.
Methods: We performed confocal fluorescence microscopy to determine subcellular localization of PCDH1 in 16HBE cells and primary bronchial epithelial cells (PBECs) grown at air-liquid interface.
Protocadherin-1 is a glucocorticoid-responsive critical regulator of airway epithelial barrier function.
BMC Pulm Med
July 2015
Nihon University School of Medicine Division of Respiratory Disease, 30-1 Ohyaguchi-Kamicho, Itabashiku, Tokyo, 173-8610, Japan.
Background: Impaired epithelial barrier function renders the airway vulnerable to environmental triggers associated with the pathogenesis of bronchial asthma. We investigated the influence of protocadherin-1 (PCDH1), a susceptibility gene for bronchial hyperresponsiveness, on airway epithelial barrier function.
Methods: We applied transepithelial electric resistance and dextran permeability testing to evaluate the barrier function of cultured airway epithelial cells.
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