A case of concomitant keratoconus and granular corneal dystrophy type II.

Cont Lens Anterior Eye

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Published: August 2014

Purpose: We report a Korean case of concomitant keratoconus and granular corneal dystrophy type II.

Methods: Case report.

Results: A 29-year-old man visited our clinic for a routine ocular check-up. Slit-lamp examination revealed a few well-circumscribed, greyish-white, discrete granular opacities in the central corneal stromae of both eyes. Direct sequencing of exon 4 of the BIGH3 gene revealed a heterozygous transversion from G to A in the second-nucleotide position of codon 124. In addition, a Fleischer ring and Vogt's striae were evident in the cornea. The corneal topography was suggestive of keratoconus.

Conclusion: Granular corneal dystrophy type II can co-exist with keratoconus and should be included in the differential diagnosis.

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Source
http://dx.doi.org/10.1016/j.clae.2014.02.001DOI Listing

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