Under urethane anesthesia multiple unit activity (MUA) recordings were taken from medial and lateral preoptic and anterior hypothalamic sites in 21 rats during multiple dose intracerebroventricular (i.vt.) injections of angiotensin II (AII), using artificial CSF as control. Olfactory stimuli were also presented. Whilst lateral sites on average were significantly less responsive to AII than were medial sites, some of the former were very responsive. None of the 14 lateral sites that yielded an MUA response to AII failed to yield an MUA response to olfactory stimulation. On the other hand, 11 of 12 medial sites that yielded an MUA response to AII failed to yield an MUA response to olfactory stimulation. On the basis of these data it is suggested that the medial and lateral regions of the basal forebrain serve different functions, the former more related to internal sensing and the latter more related to integration of internal and external sensing. The findings are discussed in relation to the dual olfactory system and to theories of motivation.
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