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Mesenchymal Stem Cell Exosomes Therapy for Acquired Trichorrhexis Nodosa: A Case Series.
J Cosmet Dermatol
November 2024
Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Background: Recent preclinical studies have demonstrated the potential efficacy of stem cell exosomes in the treatment of hair loss. However, there is a paucity of clinical studies investigating the application of exosomes for this purpose. This case series presents three patients treated with exosomes for acquired trichorrhexis nodosa (ATN), a condition characterized by hair shaft abnormalities and breakage.
View Article and Find Full Text PDFHair fragility (trichorrhexis nodosa) in alopecic Pomeranian dogs.
Vet Dermatol
February 2025
Department of Clinical Sciences and Services, Royal Veterinary College, Hatfield, Herts, UK.
Article Synopsis
- Alopecia X, a type of hair cycle arrest, is common in Pomeranian dogs, and this study explores whether these dogs also suffer from hair fragility, evidenced by hair shaft abnormalities.
- The research compared 8 alopecic Pomeranians with 36 unaffected ones, revealing significantly higher hair fragility events (66 occurrences per 10 mg) in the affected dogs compared to a reference limit of 9.75 in normal coats.
- The findings suggest that veterinarians should check for hair abnormalities in Pomeranians with HCA, indicating a need for further investigation into the causes and treatments of hair fragility in these dogs.
Hair Shaft Fracture in a Young Athlete: A Rare Case Report of Acquired Trichorrhexis Nodosa.
Cureus
August 2024
Department of Dermatology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, IND.
Article Synopsis
- - Trichorrhexis nodosa (TN) is a hair shaft disorder causing hair fragility and weak points, often resulting from daily hair care or environmental exposure, and is more commonly acquired than congenital.
- - A case study of a 19-year-old male volleyball player revealed acquired distal TN, linked to chlorine exposure and excessive training, with symptoms including abnormal hair fragility and visible white knots along the hair shafts.
- - Diagnosis was confirmed through dermoscopy and microscopy, leading to recommendations for gentle hair care; follow-up showed no recurrence after six months, emphasizing the importance of managing underlying causes.
Coexisting trichorrhexis nodosa and pili annulati: a case report of hair shaft abnormalities in a Syrian family.
Ann Med Surg (Lond)
August 2024
Department of Dermatology and Venereology, Aleppo University Hospital, University of Aleppo, Aleppo, Syrian Arab Republic.
Article Synopsis
- Pili annulati (PA) and trichorrhexis nodosa (TN) are uncommon genetic hair disorders, with PA characterized by sparkly hair due to air-filled cavities, and TN resulting in brittle, easily breakable hair shafts.
- A 23-year-old woman with both disorders showed brittle hair and whitish nodules; tests confirmed the presence of TN alongside PA, revealing unique characteristics that suggest a genetic link, as her aunt had similar symptoms.
- While PA is usually benign, its combination with TN illustrates the complexity of hair disorders and indicates that further research is needed to understand their relationship and guide effective treatment strategies.
Hair Shaft Abnormalities as a Dermoscopic Feature of Mycosis Fungoides: Pilot Results.
Dermatol Ther (Heidelb)
August 2024
Department of Dermatology, Medical University of Warsaw, Koszykowa 82a Street, 02-008, Warsaw, Poland.
Introduction: Diagnosis of persistent erythematous, scaly patches, or plaques can be complex since psoriasis (Ps), eczematous dermatitis (ED), and mycosis fungoides (MF) can be considered. Dermoscopy, which is a noninvasive diagnostic tool, is commonly used to examine blood vessels, scales, and background color; however, research on hair shaft evaluation in inflammatory dermatoses remains scarce. The aim of the study was dermoscopic evaluation of hair shafts in skin lesions localized on the non-scalp skin areas in patients diagnosed with MF, Ps, and ED.
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