Purpose: The purpose of this study was to investigate the relation between isolated discoid lateral meniscus (DLM) tears and the presence of articular cartilage lesions.
Methods: From January 2010 to January 2012, 252 consecutive patients diagnosed with an isolated DLM tear during an arthroscopic procedure were included in this study. Demographic variables, including gender, age, body mass index (BMI), traumatic history, time course, and date of the DLM tear, were recorded. The relation between DLM tears and the presence of articular cartilage lesions was analyzed by the χ(2) test. Logistic regression analysis was used to analyze the relation between these variables and articular cartilage lesions.
Results: Of the patients with DLM tears, 67 (26.6%) also had articular cartilage lesions. The most common type of DLM tear was the complex tear (46.8%). The most common location of articular cartilage lesions was the lateral tibial plateau (11.6%). Lesions on the opposing articular surfaces of the lateral compartment and patellofemoral joint of the knee were found in 12 patients (4.8%) and 11 patients (4.4%), respectively. There were no significant differences in the incidences of articular cartilage lesions in patients with different types of DLM tears (P > .05). Gender (odds ratio [OR], 2.289; P = .012), BMI (OR, 1.991; P = .023), and time course (OR, 2.050; P = .034) were significantly associated with articular cartilage lesions.
Conclusions: DLM tears were more common in the context of degenerative tears. There was no significant difference in the incidence of articular cartilage lesions among patients with different types of DLM tears. Female patients, patients with a BMI greater than 23.0 kg/m(2), or patients with a time course of greater than 6 months were more frequently observed to also have articular cartilage lesions.
Level Of Evidence: Level IV, therapeutic case series.
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http://dx.doi.org/10.1016/j.arthro.2013.11.029 | DOI Listing |
Adv Sci (Weinh)
January 2025
Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, No.7 Weiwu Road, Zhengzhou, Henan, 450003, China.
Osteoarthritis (OA) is an age-related degenerative joint disease, prominently influenced by the pro-inflammatory cytokine interleukin-6 (IL-6). Although elevated IL-6 levels in joint fluid are well-documented, the uneven cartilage degeneration observed in knee OA patients suggests additional underlying mechanisms. This study investigates the role of interleukin-6 receptor (IL-6R) in mediating IL-6 signaling and its contribution to OA progression.
View Article and Find Full Text PDFGels
January 2025
Department of Polymer Nano Science & Technology and Polymer Materials Fusion Research Center, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si 54896, Jeonbuk, Republic of Korea.
Articular cartilage faces challenges in self-repair due to the lack of blood vessels and limited chondrocyte concentration. Polydeoxyribonucleotide (PDRN) shows promise for promoting chondrocyte growth and cartilage regeneration, but its delivery has been limited to injections. Continuous PDRN delivery is crucial for effective cartilage regeneration.
View Article and Find Full Text PDFCells
January 2025
Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 970, Taiwan.
We aimed to explore the therapeutic efficacy of miR-7704-modified extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (HUCMSCs) for osteoarthritis (OA) treatment. In vitro experiments demonstrated the successful transfection of miR-7704 into HUCMSCs and the isolation of EVs from these cells. In vivo experiments used an OA mouse model to assess the effects of the injection of miR-7704-modified EVs intra-articularly.
View Article and Find Full Text PDFCurr Stem Cell Res Ther
January 2025
Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt.
Introduction: Osteoarthritis (OA) is a degenerative joint disease that can affect the many tissues of the joint. There are no officially recognized disease-modifying therapies for clinical use at this time probably due to a lack of complete comprehension of the pathogenesis of the disease. In recent years, emerging regenerative therapy and treatments with stem cells both undifferentiated and differentiated cells have gained much attention as they can efficiently promote tissue repair and regeneration.
View Article and Find Full Text PDFJ Clin Orthop Trauma
February 2025
Trauma and Orthopaedics East and North Hertfordshire NHS Trust Lister Hospital, Stevenage, UK.
Background: There has been an increasing interest in elbow hemiarthroplasty to circumvent the problems with total elbow arthroplasty for comminuted distal humerus fractures in the elderly. The primary aim of the study is to assess the mid-term clinical and radiological outcomes of patients undergoing TEA and hemiarthroplasty for distal humerus fractures.
Methods: Retrospective analysis of data for patients undergoing hemiarthroplasty for distal humerus fractures (OTA- C3 Comminuted total articular fractures) was done.
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