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Pre-infection anticoagulant exposure and SARS-CoV-2 infection outcomes - Differential mortality by age.
Thromb Res
January 2025
Department of Hematology, Hadassah University Medical Center, Jerusalem, Israel; Braun School of Public Health and Community Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Background: The risk of thrombosis increases after SARS-CoV-2 infection. This study aimed to assess associations between pre-infection anticoagulant exposure and SARS-CoV-2 infection-related outcomes in a population-based cohort.
Methods: Members of the "Meuhedet" health maintenance organization aged >45 years who tested positive for SARS-CoV-2 infection (03/2020-04/2022) were followed.
[Clinical application and technical operation specification of dual plasma molecular adsorption system].
Zhonghua Gan Zang Bing Za Zhi
December 2024
The standard clinical application and operational specifications of the double plasma molecular adsorption system are summarized into eleven parts, including the treatment principles, indications and timing selection, treatment plan formulation principles, establishment and maintenance of vascular access, anti-coagulation strategy selection, instrument alarms and handling, and the efficacy evaluation indicators in the treatment of severe liver disease.
View Article and Find Full Text PDFEfficacy, safety and dose patterns of tranexamic acid in meningioma surgery: a systematic review and updated meta-analysis of randomized controlled trials.
Neurosurg Rev
January 2025
Department of Medicine, Federal University of Sergipe, Aracaju, Brazil.
Article Synopsis
- The study examined the use and safety of intravenous tranexamic acid (TXA) in patients undergoing surgery for intracranial meningiomas, focusing on how different doses affected outcomes.
- A total of six randomized controlled trials with 881 patients were analyzed, revealing that TXA significantly reduced intraoperative blood loss, blood transfusion rates, surgery duration, and hospital stay lengths, but did not increase postoperative complications.
- The findings suggested that a preoperative dose of 20 mg/kg with an intraoperative maintenance dose was effective in minimizing blood loss, although further research is needed to confirm these observations and optimize dosing strategies.
[Clinical Analysis of 25 Cases of Acquired Hemophilia A in a Single Center].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Department of Hematology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Hematology, Shijiazhuang 050000, Hebei Province, China.
Objective: To explore the diagnosis and treatment of acquired hemophilia A (AHA) based on the analysis of clinical data.
Methods: A retrospective analysis was conducted on the clinical manifestations, laboratory characteristics, treatment, and outcomes of 25 patients diagnosed with AHA who were admitted to the Second Hospital of Hebei Medical University.
Results: Among all patients, 11 cases had secondary factors, including 5 cases of autoimmune diseases, 3 cases of pregnancy-related disease, 1 case of pemphigoid, 1 case of Graves' disease, and 1 case of monoclonal gammaglobulinemia of unknown significance (MGUS).
Early Postoperative Outcome of Continuous Heparin Infusion versus Intermittent Intravenous Heparin after Initial Bolus Dose during Off-Pump Coronary Artery Bypass Surgery: An Eminent Time worthy Study.
Mymensingh Med J
January 2025
Dr Khondokar Shamim Shahriar Ziban Rushel, Assistant Professor, Department of Cardiac Surgery, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh; E-mail:
Heparin is an anticoagulant used invariably in all cardiac surgery. Heparin dosing and its reversal were determined by monitoring activated clotting time (ACT). Intermittent heparin dosing after initial bolus dose is widely practiced to maintain ACT level 200-300 seconds in Off-pump coronary artery bypass surgery (OPCAB).
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