We investigate the failure mechanisms of load-sharing complex systems. The system is composed of multiple nodes or components whose failures are determined based on the interaction of their respective strengths and loads (or capacity and demand, respectively) as well as the ability of a component to share its load with its neighbors when needed. We focus on two distinct mechanisms to model the interaction between components' strengths and loads. The failure mechanisms of these two models demonstrate temporal scaling phenomena, phase transitions, and multiple distinct failure modes excited by extremal dynamics. For critical ranges of parameters the models demonstrate power-law and exponential failure patterns. We identify the similarities and differences between the two mechanisms and the implications of our results for the failure mechanisms of complex systems in the real world.
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http://dx.doi.org/10.1103/PhysRevE.89.012816 | DOI Listing |
ASN Neuro
January 2025
Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, USA.
Despite tremendous progress in characterizing the myriad cellular structures in the nervous system, a full appreciation of the interdependent and intricate interactions between these structures is as yet unfulfilled. Indeed, few more so than the interaction between the myelin internode and its ensheathed axon. More than a half-century after the ultrastructural characterization of this axomyelin unit, we lack a reliable understanding of the physiological properties, the significance and consequence of pathobiological processes, and the means to gauge success or failure of interventions designed to mitigate disease.
View Article and Find Full Text PDFInt J Endocrinol
January 2025
Nephrology Department, Jiangxi Provincial Key Research Laboratory of Traditional Chinese Medicine, Key Research Laboratory of Chronic Renal Failure, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006, China.
This study aimed to investigate the potential mechanisms of puerarin in alleviating diabetic nephropathy (DKD) in mice. The DKD model was induced by multiple low-dose injections of streptozotocin (STZ) and a high-sugar and high-fat diet in male C57BL/6J mice. After confirming the onset of DKD, mice were given irbesartan, distilled water, or different concentrations of puerarin (40 and 80 mg/kg/d) by gavage for 8 weeks.
View Article and Find Full Text PDFTurk J Emerg Med
January 2025
Department of Emergency Medicine, Çukurova University School of Medicine, Adana, Türkiye.
Mushrooms have been consumed frequently worldwide since ancient times. In addition to edible and harmless species, there are also poisonous species that cause a wide range of clinical syndromes, from simple gastrointestinal (GI) irritation to death. However, it is not possible to distinguish the poisonous species from some edible species morphologically.
View Article and Find Full Text PDFCureus
December 2024
Orthopedic Surgery, Middlebrook Family Medicine, Middlebrook, USA.
The treatment for osteoarthritis (OA) often requires total joint arthroplasty (TJA) when less invasive approaches fail. The annual incidence of TJA is rising. Metal-on-metal (MoM) hip and knee implants were widely used for TJA in the past, but complications have led to their decline.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Shengli Clinical College of Fujian Medical University, Department of Pharmacy, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Objective: Although there are certain drug categories associated with heart failure (HF), most of the associated risks are unclear. We investigated the top drugs associated with HF and acute HF (AHF) reported in the FDA Adverse Event Reporting System (FAERS).
Methods: We reviewed publicly available FAERS databases from 2004 to 2023.
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