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Topical use of chicory root extract gel on the incidence and severity of radiodermatitis in breast cancer patients: a randomized controled trial.
Support Care Cancer
November 2024
The Advocate Center for Clinical Research, Ayatollah Yasrebi Hospital, Kashan, Iran.
Background And Purpose: Nearly 95% of women treated with radiotherapy for breast cancer experience some degree of radiodermatitis. Radiation therapy's most frequent side effect is skin damage. Managing radiation-induced skin reactions while maintaining treatment continuity is a challenging issue.
View Article and Find Full Text PDFEffects of inulin-type oligosaccharides (JSO) from . on behavioral deficits induced by chronic restraint stress in mice and associated molecular alterations.
Front Pharmacol
November 2024
Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Depression and anxiety are serious psychiatric disorders with significant physical and mental health impacts, necessitating the development of safe and effective treatments. This study aimed to evaluate the efficacy of oligosaccharide (JSO), a type of inulin-based oligosaccharide, in alleviating anxiety and depression and to investigate the underlying molecular mechanisms. Using a mouse model of chronic restraint stress (CRS), JSO was administered orally at doses of 50, 100, and 200Â mg/kg for 21Â days.
View Article and Find Full Text PDFLactucin ameliorates FFA-induced steatosis in HepG2 cells by modulating mitochondrial homeostasis through the SIRT1/PGC-1α signaling axis.
Heliyon
November 2024
Key Laboratory of Active Components of Xinjiang Natural Medicine and Drug Release Technology, Urumqi, 830000, China.
Nonalcoholic fatty liver disease is a complex disease involving abnormal liver metabolism. Its strong association with metabolic dysfunction has led to a change in nomenclature to metabolism dysfunction-associated fatty liver disease (MAFLD). MAFLD pathogenesis involves abnormal accumulation of hepatic lipids that lead to the production of excess free fatty acids (FFAs), which in turn cause an imbalance in hepatic mitochondrial function.
View Article and Find Full Text PDFEfficacy and safety of a polyherbal formulation in the management of urinary tract infection.
Drug Metab Pers Ther
November 2024
Department of Moalajat, School of Unani Medical Education & Research, Jamia Hamdard, New Delhi, India.
Objectives: Urinary tract infection (UTI) is one of the most frequent reasons for prescribing antibiotics. implicated in 75-90 % cases of UTI is becoming increasingly resistant to antibiotics. Finding alternative therapeutic agent for this infection is critical, for which herbal drugs may be an option.
View Article and Find Full Text PDFHerbal Amara extract induces gastric fundus relaxation via inhibition of the M2 muscarinic receptor.
Neurogastroenterol Motil
January 2025
Preclinical Research and Development, Weleda AG, Arlesheim, Switzerland.
Background: Impaired gastric accommodation is one of the most frequent symptoms of functional dyspepsia. The safety and efficacy of conventional treatments remain to be proven and alternative herbal therapies have been proposed to alleviate gastrointestinal symptoms. This preclinical study examined the role of herbal Amara extract (containing Artemisia absinthium, Centaurium erythraea, Cichorium intybus, Gentiana lutea, Juniperus communis, Achillea millefolium, Peucedanum ostruthium, Salvia officinalis, and Taraxacum extracts) on gastric (fundus) accommodation and the possible implication of muscarinic receptors in its regulation.
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