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S1 guideline: Differential diagnosis of acute and chronic redness of the lower legs.
J Dtsch Dermatol Ges
July 2022
Department of Dermatology, Venereology and Allergology, Division of Evidence-Based Medicine (dEBM), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.
Acute or chronic redness of the lower leg is a frequent reason for visits to clinics and practices. The differential diagnosis is often challenging. The aim of this guideline is to define criteria and procedures for the differential diagnosis of acute or chronic, unilateral or bilateral redness of the lower leg.
View Article and Find Full Text PDFSince its onset, the new coronavirus SARS-CoV-2 has manifested multiple paradoxes related to both complications of the infection and treatment resistance. The experiences in therapy started from the use of neutralizing monoclonal antibodies and anti-cytokine therapy (anti IL-6, anti-TNF-alpha and CCR5) up to experiments of immunomodulation with glucocorticoids and proposal of very powerful immunomodulatory drugs like cyclophosphamide in optimized diagrams in order to induce the depression of the immune hyperergic reaction with the maintenance of TH and TC lymphocyte resistance to keep the anti-viral activity in the absence of an etiological treatment. In this context, also the second major immunologic mechanism could function: the molecular mimicry - cross-reactivity between viral epitopes and various antigenic determinants from the body, other than the tissue structures of the respiratory system.
View Article and Find Full Text PDF[Features of neurological manifestations of the COVID-19 in children and adults].
Zh Nevrol Psikhiatr Im S S Korsakova
October 2020
Pirogov Russian National Research Medical University, Moscow, Russia.
The number of COVID-19 patients is increasing worldwide and the number of patients with neurological manifestations of a new coronavirus infection is increasing as well. Pathognomonic for COVID-19 is the presence of cephalgic syndrome, infectious-toxic encephalopathy, hypo- and anosmia and ageusia. Inducing of pathological autoimmune response contributes to the development of Miller Fischer and Guillain-Barré syndrome.
View Article and Find Full Text PDFHematological reactions in the inhabitants of the Arctic on a polar night and a polar day.
Immun Inflamm Dis
September 2020
Research Centre for Human Adaptation in the Arctic, Branch of the Federal Research Centre "Kola Science Centre of the Russian Academy of Sciences", Apatity, Russia.
Purpose: The purpose of this study is to identify the features of hematological reactions in the inhabitants of the Arctic territory of the Kola Peninsula on a polar night and a polar day.
Methods: The study included determining the hemogram, neutrograms, monocytograms, lymphocytograms, and phagocytic activity neutrophil granulocytes, enzyme immunoassay, flow cytometry.
Results: It was established that during the polar night, there is an increase in the activity of migration of leukocytes from the marginal pool to the circulating pool, an increase in the intensity of phagocytosis by neutrophils, an increase in the concentrations of noradrenaline, cortisol, as well as an increase in hyperergic reactions involving immunoglobulin E and inhibitory processes due to an increase in interleukin-10.
In vitro and in vivo biocompatibility and bio-tribological properties of the calcium/amorphous-C composite films for bone tissue engineering application.
Colloids Surf B Biointerfaces
April 2020
Anhui Province Key Lab of Aerospace Structural Parts Forming Technology and Equipment, Hefei University of Technology, Hefei, 230009, China; National-Local Joint Engineering Research Centre of Nonferrous Metals and Processing Technology, Hefei 230009, China.
Carbon-and diamond-like-carbon coated Ti alloys hold great promise for tissue engineering applications. Unfortunately, their strong intrinsic stress leads to the adhesion failure of the films. Herein, a series of a-C films with different Ca content were prepared on TiAlV via co-sputtering deposition technology.
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